Gastric Protective Effects of <i>Banhasasim-tang</i> on
Indomethacin-treated Rats

Park, Su-wan; Byun, Joon-seok

The Journal of Internal Korean Medicine > Volume 35(2); 2014 > Article

Original Article

The Journal of Internal Korean Medicine 2014;35(2): 208-221.

Gastric Protective Effects of Banhasasim-tang on Indomethacin-treated Rats

Su-wan Park, Joon-seok Byun

Dept. of Internal Medicine, College of Oriental Medicine, Daegu Haany University

Correspondence

Joon-seok Byun ,Tel: 053-770-2192, Fax: 053-770-2055, Email: kissplzz@hanmail.net

Published online: June 30, 2014.

ABSTRACT

Purpose:
Banhasasim-tang (BHSST) has been applied for treating the symptom of gastric stuffiness, which is similar to dyspepsia. The object of this study was to observe the healing effect of BHSST on the indomethacin (IND)-induced gastric ulcer in rats.

Methods :
Three different dosages of BHSST (400, 200 and 100 mg/kg) were orally administered 30 min before IND treatment; 6 hrs after IND treatment, the changes on the gross lesion scores, fundic histopathology, myeloperoxidase (MPO) activity, lipid peroxidation and antioxidant defense system (glutathione contents, catalase (CAT) and superoxide dismutase (SOD) activities) were observed, and compared with the activity of the synthetic anti-ulcer drug, a representative proton pump inhibitor omeprazole (OME) 10 mg/kg.

Results:
All three different dosages of BHSST treatment in the IND-induced gastric ulcer rats, significant and dose dependent decreased gastric damages - hemorrhagic gross lesions, gastric mucosa MPO levels and histopathological gastric ulcerative lesions - were detected as compared with the IND treated control rats. BHSST also strengthened the antioxidant defense systems – decreased the level of lipid peroxidation and CAT activity but increased the level of GSH and SOD activity, and BHSST 200 mg/kg showed similar anti-ulcerative effect as compared with OME 10 mg/kg.

Conclusions:
The results obtained in this study suggest that BHSST has favorable effects against IND-induced gastric damages, through significant and dose-dependent decreasing gastric damages and the strengthening of the body’s antioxidant defense systems with direct anti-inflammatory effects.

Key words: Banhasasim-tang (BHSST), gastric ulcer, indomethachin (IND), omeprazole (OME)