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The Journal of Internal Korean Medicine > Volume 35(3); 2014 > Article
The Journal of Internal Korean Medicine 2014;35(3): 288-297.
황련해독탕 추출액의 각막염 원인균에 대한 항균효과
김인수1, 서진종2, 김광곤2, 하동룡2, 신민구1, 김의수1, 전상윤1
1동신대학교 한의과대학 내과학교실
2광주광역시 보건환경연구원
Antimicrobial Activity of Hwangryunhaedok-tang Extract against Keratitis
In-soo Kim1, Jin-jong Seo2, Kwang-gon Kim2, Dong-ryong Ha2, Min-koo Shin1, Eui-su Kim1, Sang-yun Jeon1
1Dept. of Internal Medicine, College of Korean Medicine, Dong-Shin University
2Health and Environment Institute of Gwangiu
Correspondence  Sang-yun Jeon ,Tel: 062-350-7207, Fax: 062-350-7141, Email: damiano70@hanmail.net
  Published online: September 30, 2014.
ABSTRACT
Objectives:
The goal of this project was to measure the antibacterial effectiveness of Hwangryunhaedok-tang (barberry root decoction for detoxification) and its constituents. All of the active ingredients including the final product were prepared using high-pressure sterilization for use as medicinal eye drops. The varying forms of Hwangryunhaedok-tang (barberry root decoction for detoxification) were used to treat Staphylococcus epidermidis and Enterococcus faecalis which are found in keratitis.

Methods:
The antibacterial effect was measured by observing the presence or absence of antimicrobial activity when treated with varying concentrations of Hwangryunhaedok-tang extract. The tests were performed using a dosage of 70 μl dosages of 100%, 50%, 10% and 1% the extracted solution by the minimum growth inhibitory concentration measurement. Antimicrobial activity was measured by examining the correlation between dosage strength and bacterial activity from 70 μl to 10 μl at the same concentration.

Results:
1. Hwangryunhaedok-tang (barberry root decoction for detoxification), Phellodendri Cortex, and gardenia didn't show any antimicrobial effects against S. aureus, S. epidermidis, or E. faecalis. 2. Barberry root showed antimicrobial effects against S. aureus and S. epidermidis depending on the levels of concentration but didn't show any antimicrobial effects against E. faecalis. 3. Skullcap showed antimicrobial effects against S. aureus and S. epidermidis when a dosage of 100% extract 70 μl was used. However, did not show any antimicrobial effects at all against E. faecalis.

Conclusions:
Hwangryunhaedok-tang (barberry root decoction for detoxification) and its constituents such as barberry root, phellodendri cortex, skullcap, and gardenia, can be used as an alternative to antibiotic medicinal eye drops to treat keratitis. However, further research on effective uses of and efficient extraction methods are needed.
Key words: Hwangryunhaedok-tang (huanglianjiedu-tang), Keratitis, S. aureus, S. epidermidis, Enterococcus faecalis
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