| 淸上補下湯의 기관지천식환자에 대한 스테로이드 절약효과 |
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| The Steroid Sparing Effects of Cheongsangboha-tang in Asthmatic Patients |
| Woo-Suck Hwang, Jun-Yong Choi, Jae-Sung Lee, Chang-Yeop Ju, Hee-Jae Jung, Hyung-Koo Rhee, Sung-Ki Jung |
| Division of Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea |
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Received: September 23, 2002, Accepted: October 19, 2002, Published online: March 30, 2003. |
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| ABSTRACT |
Background:
In recent years, the glucocorticoid hormone has become a fundamental medication for asthma. However, a long period of hormone administration will result, in general, side effects on many body parts as well as hormone dependence, which has become a serious problem for western physicians.
Objectives:
We aimed to identify the clinical effects of Cheongsangboha-tang and the steroid sparing effects of Cheongsangboha-tang on.
Materials and Methods :
A subject group consists of 36 asthmatics who had been treated with Cheongsangboha-tang for four weeks. Cheongsangboha-tang is a herbal decoction, which has been used of the traditional therapeutic agent of asthma. PFT, QLQAKA, blood eosinophil, serum IgE, Serum IL-4, IL-5, IFN- were checked before and 4weeks after the treatment.
Results:
The only FVC% in ICSG among asthmatic patients was increased significantly compared to NICSG. Treatment of Cheongsangboha-tang for four weeks resulted in significant increase in QLQAKA. The NICSG treated with Cheongsangboha-tang for four weeks were no significant difference in the blood eosinophil, serum IgE, IL-4 and IL-5. The PFT and QLQAKA in NICSG were increased significantly after 4 weeks treatment. But the serum IFN- in NICSG was decreased significantly after 4 weeks treatment. Discontinuation of treatment with inhaled corticosteroid in ICSG resulted in insignificant changes in PFT, the blood eosinophil, the serum IgE, IL-4, IL-5 and IFN- and significant increase in QLQAKA. As a result, 8 of 13 cases were cured with hormones completely and the rest of ICSG reduced the dose of ICS.
Conclusions:
This study shows that Cheongsangboha-tang has the effects on the improvement of pulmonary function and cures asthmatic patients. These findings demonstrate that Cheongsangboha-tang has the steroid sparing effect. Some satisfactory therapeutic results have been obtained in treating hormone-dependent asthma by Cheongsangboha-tang. However, the concept and mechanism of hormone-dependent asthma have not been fully defined yet, and the standard for judging therapeutic effects have not been established. Obviously further researches concerning all these are still necessary. |
| Key words:
Cheongsangboha-tang(Qingshangbuxia-tang), asthma, steroid sparing effect, cytokines |
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