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The Journal of Internal Korean Medicine > Volume 34(4); 2013 > Article
The Journal of Internal Korean Medicine 2013;34(4): 362-374.
역류성 식도염 유발 생쥐의 半夏瀉心湯 투여 효과에 대한 실험 연구
장명웅, 임성우
동국대학교 한의과대학 일산한방병원 한방내과
Experimental Study for Effect of Banhasasim-tang on Mice with Reflux Esophagitis
Myeong-woong Jang, Seong-woo Lim
Dept. of Oriental Internal Medicine, Dong-Guk University, Il-san Oriental Medicine Hospital
Correspondence  Seong-woo Lim ,Tel: 031-961-9043, Fax: 031-961-9049, Email: omdlsw@naver.com
  Published online: December 30, 2013.
This study was carried out to investigate the inhibitory effect of Banhasasim-tang on early reflux esophagitis by control of gastric peristalsis and the lower esophageal sphincter in mice.

Methods :
Experimental mice were classified into three groups. The normal group were mice with no inflammation. The control group were mice with gastroesophageal reflux elicited by alcohol. The sample group were mice administered Banhasasim-tang after gastroesophageal reflux elicitation. We observed morphological change and production of ghrelin, substance P, and inducible nitric oxide synthase (iNOS) in gastroesophageal junction mucosa. In addition, we examined change of epithelial junction in esophageal mucosa and change of lower esophageal sphincter distribution.

The migration of inflammation-related cells in lamina propria of gastroesophageal junction decreased more in the sample group than in the control group. The positive reaction of ghrelin, substance P, and iNOS significantly decreased more in the sample group than in the control group (p < 0.05). Injury of the epithelial junction in the esophageal mucosa and outer oblique layer in the lower esophageal sphincter were significantly mitigated by Banhasasim-tang administration in the sample group (p < 0.05).

According to the above results, it is supposed that Banhasasim-tang inhibits early reflux esophagitis by controlling not only gastric peristalsis and acid secretion through ghrelin, and substance P but also the lower esophageal sphincter through iNOS.
Key words: Banhasasim-tang (bànxiàxièx l̄n-tāng), reflux esophagitis, ghrelin, substance P, nitric oxide, lower esophageal sphincter
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