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The Journal of Internal Korean Medicine > Volume 29(4); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(4): 1037-1047.
Hepatoprotective Effects of GongJin-dan on Ethanol-mediated Experimental Liver Damage in Rats
Hyun Hur, Hee-jun Kim, Kyung Park, Min-a Kwak, Dae-jun Kim, Joon-seok Byun
Department of Oriental Medicine, Daegu Haany University
Correspondence  Hee-jun Kim ,Tel: 053-770-2179, Fax: 053-764-0566, Email: heejuny513@hanmail.net
  Published online: December 30, 2008.
ABSTRACT
Background:
A traditional Oriental medicine, GongJin-dan (GJD), is one of the most well-known tonic agents in Korea. Among 6 types of GJD components, antler, red ginseng, and Cornus fructus have shown antioxidant effects, while EtOH-induced tissue damage may be a consequence of oxidative stress.

Objectives & Methods :
The hepatoprotective effects of GJD were evaluated on EtOH-mediated experimental liver damaged rats at 50, 100, 250 and 500mg/kg comparing with 100mg/kg of silymarin as a reference drug in the present study. Test substances were dosed once a day for 60 days with oral administration of 20% ethanol 2.5ml/100g body weight twice a day (equivalent to 7.9g ethanol/kg/day). Each of 8 rats per group was selected using body weight at 10 days after acclimatization. Experimental animals were sacrificed after 60 days of continuous oral treatment of test substances with 20% ethanol treatment, and changes on the body weight, liver weight, and serum AST and ALT were observed.

Results:
There were dramatic decreases of body weight and increases of liver weight and serum AST and ALT. Similar inhibition effects on the EtOH-induced hepatic damages were detected between equal dosages of GJD and silymarin.

Conclusion:
Based on these results, it is concluded that GJD showed clear hepatoprotective effects on EtOH-induced hepatic damage.
Key words: Hepatoprotective, GongJin-dan, Ethanol-mediated, Liver damage
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