The Effects of Gypsum on Streptozotocin-induced Diabetic Nephropathic Rats

Hong, Gwang-hae; Lee, Kwun-ho; Jeong, Gi-hoon; Kim, Young-seong; Lee, Hyun-ju

The Journal of Internal Korean Medicine > Volume 29(4); 2008 > Article

Original Article

The Journal of Internal Korean Medicine 2008;29(4): 1025-1036.

石膏가 streptozotocin으로 유발된 rat의 糖尿病性腎症에 미치는 影響

홍광해¹, 이권호¹, 정기훈¹, 김용성¹, 이현주²

¹동신대학교 한의과대학 신계내과학교실
²제인한방병원 한방내과

The Effects of Gypsum on Streptozotocin-induced Diabetic Nephropathic Rats

Gwang-hae Hong¹, Kwun-ho Lee¹, Gi-hoon Jeong¹, Young-seong Kim¹, Hyun-ju Lee²

¹Dept. of Internal Medicine. College of Oriental Medicine, Dongshin University
²Oriental Internal Medicine, Jein Hospital of Oriental Medicine

Correspondence

Gi-hoon Jeong ,Tel: 061-280-7921, Fax: 061-280-7788, Email: underlo@hanmail.net

Published online: December 30, 2008.

ABSTRACT

Objectives:
The aim of present study was to investigate recovery effects of gypsum, which has been used clinically in diabetes therapy.

Methods :
We established three groups, normal, control, and gypsum, and assigned 6 rats to each group. The normal group was not treated by any process and fed normal saline. The control & gypsum groups were administered streptozotocin(STZ) to induce diabetes. Gypsum extract was orally administered to the gypsum group for 10 days. After 8 weeks, the rats were sacrificed and their body weight, 24hrs urinary protein excretion, glucose, albumin, BUN, creatinine, total-cholesterol, LDL-cholesterol, triglyceride in blood, level of glycation end-product (AGE) and transforming growth factor (TGF-β1) in serum were measured. Morphological profiles and morphometric studies of the kidney cortex, renal transforming growth factor (TGF-β1) expression, macrophage/monocyte antigen (ED-1), and type IV collagen expression were studied.

Results:
The following results were obtained. The protein amount in urine per 24hrs of the gypsum-treated group as compared to the control was significantly reduced. The BUN and creatinine level in serum of the gypsum-treated group as compared to the control was significantly inhibited. The construction change in the kidneys of the gypsum-treated group as compared to the control was significantly inhibited. The factor of the gypsum-treated group as compared to the control was significantly inhibited, which induced the structural change in the kidneys.

Conclusions:
The above results suggest that gypsum partially improved kidney function.

Key words: Gypsum, Streptozotocin, Diabetic Nephropathic Rats