| Home | E-Submission | Sitemap | Editorial Office |  
top_img
The Journal of Internal Korean Medicine > Volume 29(4); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(4): 1025-1036.
石膏가 streptozotocin으로 유발된 rat의 糖尿病性 腎症에 미치는 影響
홍광해1, 이권호1, 정기훈1, 김용성1, 이현주2
1동신대학교 한의과대학 신계내과학교실
2제인한방병원 한방내과
The Effects of Gypsum on Streptozotocin-induced Diabetic Nephropathic Rats
Gwang-hae Hong1, Kwun-ho Lee1, Gi-hoon Jeong1, Young-seong Kim1, Hyun-ju Lee2
1Dept. of Internal Medicine. College of Oriental Medicine, Dongshin University
2Oriental Internal Medicine, Jein Hospital of Oriental Medicine
Correspondence  Gi-hoon Jeong ,Tel: 061-280-7921, Fax: 061-280-7788, Email: underlo@hanmail.net
  Published online: December 30, 2008.
ABSTRACT
Objectives:
The aim of present study was to investigate recovery effects of gypsum, which has been used clinically in diabetes therapy.

Methods :
We established three groups, normal, control, and gypsum, and assigned 6 rats to each group. The normal group was not treated by any process and fed normal saline. The control & gypsum groups were administered streptozotocin(STZ) to induce diabetes. Gypsum extract was orally administered to the gypsum group for 10 days. After 8 weeks, the rats were sacrificed and their body weight, 24hrs urinary protein excretion, glucose, albumin, BUN, creatinine, total-cholesterol, LDL-cholesterol, triglyceride in blood, level of glycation end-product (AGE) and transforming growth factor (TGF-β1) in serum were measured. Morphological profiles and morphometric studies of the kidney cortex, renal transforming growth factor (TGF-β1) expression, macrophage/monocyte antigen (ED-1), and type IV collagen expression were studied.

Results:
The following results were obtained. The protein amount in urine per 24hrs of the gypsum-treated group as compared to the control was significantly reduced. The BUN and creatinine level in serum of the gypsum-treated group as compared to the control was significantly inhibited. The construction change in the kidneys of the gypsum-treated group as compared to the control was significantly inhibited. The factor of the gypsum-treated group as compared to the control was significantly inhibited, which induced the structural change in the kidneys.

Conclusions:
The above results suggest that gypsum partially improved kidney function.
Key words: Gypsum, Streptozotocin, Diabetic Nephropathic Rats
Editorial Office
Dongguk University Ilsan Oriental Hospital
27, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326 Korea
TEL: +82-31-961-9046   FAX: +82-31-961-9049   E-mail: jikm.edit@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Society of Internal Korean Medicine. All rights reserved.                 Developed in M2Community      |      Admin Login