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The Journal of Internal Korean Medicine > Volume 33(4); 2012 > Article
The Journal of Internal Korean Medicine 2012;33(4): 429-437.
단삼투여가 고지방식이로 유발된 비만형 당뇨병 동물모델에 미치는 영향
최선욱1, 김동훈1, 최승범1, 박근희2, 김용성1
1동신대학교 한의과대학 내과학교실
2동신대학교 한의과대학 사상의학교실
The Effects of Salvia miltiorrhiza on High Fat Diet-induced Obese Diabetic Mouse Model
Seon-wook Choi1, Dong-hoon Kim1, Seung-bum Choi1, Geun-hee Park2, Young-seung Kim1
1Dept. of internal Medicine of Oriental Medicine, Dong-Shin University
2Dept. of Sasang Constitutional Medicine of Oriental Medicine, Dong-Shin University
Correspondence  Young-seung Kim ,Tel: 061-280-7902, Fax: 061-330-7788, Email: underlo@hanmail.net
  Published online: December 30, 2012.
Obesity is an important cause of diabetes, and lipotoxicity causes insulin resistance. In this study, we investigated the effects of Salvia miltiorrhiza on high fat diet-induced obese type 2 diabetic mouse models.

Methods :
Diabetes was induced in ICR male mouse (23∼25 g) with Surwit's high fat, high sucrose diet. Mice were divided into 4 groups (n=10) of normal, control, Salvia miltiorrhiza, and metformin. After 8 weeks, body weight, OGTT, fructosamine, lipid profile, serum level of adiponectin and leptin, epididymal fat pad, liver weight and epididymal adipocyte size were measured.

Salvia miltiorrhiza significantly reduced oral glucose tolerance levels, fructosamine serum level, epididymal fat weight, and epididymal adipocyte size. Salvia miltiorrhiza also increased HDL-cholesterol, adiponectin and leptin serum levels.

These results show that Salvia miltiorrhiza improves insulin resistance. Therefore we suggest that Salvia miltiorrhiza would be an effective treatment for obese type 2 diabetic patients.
Key words: Salvia miltiorrhiza, insulin resistance, type 2 diabetes, obesity
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