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The Journal of Internal Korean Medicine > Volume 33(4); 2012 > Article
The Journal of Internal Korean Medicine 2012;33(4): 429-437.
단삼투여가 고지방식이로 유발된 비만형 당뇨병 동물모델에 미치는 영향
최선욱1, 김동훈1, 최승범1, 박근희2, 김용성1
1동신대학교 한의과대학 내과학교실
2동신대학교 한의과대학 사상의학교실
The Effects of Salvia miltiorrhiza on High Fat Diet-induced Obese Diabetic Mouse Model
Seon-wook Choi1, Dong-hoon Kim1, Seung-bum Choi1, Geun-hee Park2, Young-seung Kim1
1Dept. of internal Medicine of Oriental Medicine, Dong-Shin University
2Dept. of Sasang Constitutional Medicine of Oriental Medicine, Dong-Shin University
Correspondence  Young-seung Kim ,Tel: 061-280-7902, Fax: 061-330-7788, Email: underlo@hanmail.net
  Published online: December 30, 2012.
ABSTRACT
Objectives:
Obesity is an important cause of diabetes, and lipotoxicity causes insulin resistance. In this study, we investigated the effects of Salvia miltiorrhiza on high fat diet-induced obese type 2 diabetic mouse models.

Methods :
Diabetes was induced in ICR male mouse (23∼25 g) with Surwit's high fat, high sucrose diet. Mice were divided into 4 groups (n=10) of normal, control, Salvia miltiorrhiza, and metformin. After 8 weeks, body weight, OGTT, fructosamine, lipid profile, serum level of adiponectin and leptin, epididymal fat pad, liver weight and epididymal adipocyte size were measured.

Results:
Salvia miltiorrhiza significantly reduced oral glucose tolerance levels, fructosamine serum level, epididymal fat weight, and epididymal adipocyte size. Salvia miltiorrhiza also increased HDL-cholesterol, adiponectin and leptin serum levels.

Conclusions:
These results show that Salvia miltiorrhiza improves insulin resistance. Therefore we suggest that Salvia miltiorrhiza would be an effective treatment for obese type 2 diabetic patients.
Key words: Salvia miltiorrhiza, insulin resistance, type 2 diabetes, obesity
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