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The Journal of Internal Korean Medicine > Volume 29(3); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(3): 787-799.
단삼이 당뇨병성 신병증 Rat의 신기능 및 조직학적 변화에 미치는 영향
김영석, 이병철, 안세영, 두호경, 안영민
경희대학교 한의과대학 신계내과학교실
The Effects of Salvia Miltiorrhiza on Renal Function and Histopathological Changes in Streptozotocin-induced Diabetic Nephropathy Rat Model
Young-seok Kim, Byung-cheol Lee, Se-young Ahn, Ho-kyung Doo, Young-min Ahn
Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
Correspondence  Young-min Ahn ,Tel: 02-958-9097, Fax: 02-958-9158, Email: omdan@hanmail.net
  Published online: September 30, 2008.
ABSTRACT
Objective :
Diabetic nephropathy is the most common cause of end stage renal disease. AGE, TGF-β1, type Ⅳ collagen, and macrophage/monocyte infiltration are the main factors of diabetic nephropathy. We investigated the effects of Salvia miltiorrhiza on renal function and histopathological changes in streptozotocin(STZ)-induced diabetic nephropathy rat model.

Methods :
Diabetes was induced in male Sprague-Dawley rats(290±10g) by injecting STZ(45㎎/㎏) into the tail vein. Rats were divided into 3 groups(n=6): normal, control, and salvia. After 8 weeks of administration of Salvia miltiorrhiza extract on the Salvia group, we checked 24 hrs urine, blood biochemistry and renal tissue to evaluate renal function and histopathological changes by examining parameters including albuminuria, BUN, creatinine, cholesterol, LDL, TG, macrophage/monocyte antigen(ED-1), TGF-β1, AGE, and type Ⅳ collagen.

Results:
Salvia miltiorrhiza decreased the amount of 24hrs proteinuria, and inhibited histopathological changes of diabetic nephropathy including the expression and accumulation of various factors which could promote development of diabetic nephropathy.

Conclusion:
These findings suggest that Salvia miltiorrhiza might protect the renal function and inhibit the development of renal injury by regulating factors including AGE, TGF-β1, Type Ⅳ collagen, macrophage and monocyte infiltration. So Salvia miltiorrhiza can be used for diabetic patients to prevent the progression of diabetic nephropathy.
Key words: Diabetic Nephropathy, Salvia Miltiorrhiza, Streptozotocin, AGE, Type Ⅳ collagen, ED-1, TGF-β1
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