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The Journal of Internal Korean Medicine > Volume 29(4); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(4): 1000-1010.
吳茱萸가 PTU로 유발된 갑상선기능저하증 Rat의 갑상선기능 및 조직학적 변화에 미치는 영향
강철호, 송문구, 강지석, 이병철, 안영민, 두호경, 안세영
경희대학교 한의과대학 신계내과학교실
The Effects of Evodiae fructus on Thyroid Function and Histological Modification in Hypothyroidism Rat Model Induced by PTU.
Chul-ho Kang, Moon-koo Song, Ji-suck Kang, Byung-cheol Lee, Young-min Ahn, Ho-kyung Doo, Se-young Ahn
Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
Correspondence  Se-young Ahn ,Tel: 02-958-9153, Fax: 02-958-9158, Email: ajhj@unitel.co.kr
  Published online: December 30, 2008.
ABSTRACT
Objective :
Hypothyroidism is a syndrome characterized by symptoms such as cold intolerance, or weight gain. Because of side effects of Western medicine treatment, interest in oriental medicine has been increasing. In this study, we examined the therapeutic effects of Evodiae fructus and histological modification in hypothyroidism rat model induced by PTU(6-propyl, 2-thiouracil).

Methods :
After inducing hypothyroidism in the rats by PTU injections, we divided the rats into four groups, the Evodiae fructus 100․500, control, and LT4 (levothyroxine) groups. After 2 weeks Evodiae fructus and LT4 were administered, respectively. The weight was measured once a week. After sampling the blood for biochemical analysis to check the levels of T3, T4 and TSH, the thyroid tissue was removed, stained with H&E, and an image was obtained using an optical microscope.

Results:
Compared with normals, controls showed low T4 and high TSH. The Evodiae fructus group showed a statistically meaningful T3 increase to be dose related. But the levels of TSH showed no meaningful difference between the Evodiae fructus group and normals. About the biochemical tests(liver, kidney etc) and weight change, there was no meaningful difference between the Evodiae fructus group and controls. In the biopsy, the Evodiae fructus group showed thyroid tissue improvement compared to controls.

Conclusions:
These results show that Evodiae fructus stimulates the decreased functions of the thyroid, and also has thyroid cell protecting effects. The lab results also showed that Evodiae fructus is a safe substance that doesn’t cause hepatotoxicity or nephrotoxicity. Therefore it is an effective substance in the treatment of hypothyroidism.
Key words: Evodiae fructus, 6-Propyl, 2-thiouracil, Levothyroxine, Hypothyroidism.
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