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The Journal of Internal Korean Medicine > Volume 27(3); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(3): 677-687.
乾薑이 PTU로 유발된 Rat의 갑상선 기능저하증에 미치는 영향
강기훈, 이병철, 안세영, 두호경, 안영민
경희대학교 한의과대학 신계내과학교실
The Effects of Zingiberis rhizoma on Hypothyroidism Rat induced by PTU
Ki-Hoon Kang, Byung-Cheol Lee, Se-Young Ahn, Ho-Kyung Doo, Young-Min Ahn
Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea
Correspondence  Young-Min Ahn ,Tel: 02-958-9097, Fax: 02-958-9158, Email: omdan@hanmail.net
  Published online: September 30, 2006.
ABSTRACT
Objective :
Hypothyroidism is a common disease of the endocrinal system, characterized by fatigue, cold intolerance, bradycardia, and so on. Clinically, Levothyroxine(L-T4) has been usually used for replacement therapy, but it often has side effects, so many hypothyroidism patients wants oriental medical therapy. Zingiberis rhizoma, traditionally has been used in treatment of coldness, fatigue, and bradycardia. In this study, I investigated the therapeutic effects of Zingiberis rhizoma on PTU induced hypothyroidism in rats.

Methods :
I used two-month-old rats administered PTU and induced with hypothyroidism. After 2 weeks, Zingiberis rhizoma and thyroxine were daily administered, respectively. Body weights was measured every weeks. After 4 weeks, blood samples were taken and analyzed biochemically and T4 and TSH were measured by ELISA kits.

Results:
In comparison with normal groups, control groups showed hypothyroidism with low T4 and high TSH level. In Zingiberis rhizoma administration groups were observed T4 level elevation, this elevation was dependent on the dose of Zingiberis rhizoma. Between experimental groups and control groups, there was no difference in TSH level, statistically. Changes of biochemistry were not observed in any experimental groups.

Conclusions:
These findings suggest that Zingiberis rhizoma makes thyroid cells producing thyroid hormones. There is also a non-toxic effect on the cardiovascular system, liver and kidney function. So, Zingiberis rhizoma should be an effective agents for treating hypothyroidism.
Key words: Zingiberis rhizoma, Hypothyroidism, Anjeonleejoong-tang, PTU, Rat
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