| 加味淸熱導痰湯이 DOCA-salt로 유발된 고혈압 백서에 미치는 영향 |
| 백혜기, 안정조, 조현경, 유호룡, 김윤식, 설인찬 |
| 대전대학교 한의과대학 심계내과학교실 |
| Effects of Gamichungyeoldodam-tang(GCDT) in DOCA-salt Induced Hypertensive Rats |
| Hye-ki Baek, Joung-jo An, Hyun-kyung Jo, Ho-ryong Yoo, Yoon-sik Kim, In-chan Seol |
| Department of Internal Medicine, College of Oriental Medicine, Daejeon University |
| Correspondence |
In-chan Seol ,Tel: 042-229-6805, Fax: 042-254-3403, Email: seolinch@dju.ac.kr
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Published online: September 30, 2008. |
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| ABSTRACT |
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This study was done to investigate the effect of Gamichungyeoldodam-tang (GCDT) in DOCA-salt induced hypertensive rats. The results were obtained as follows : GCDT showed safety against cytotoxicity and toxicity in the liver and the kidney. GCDT showed an inhibitory effect on ACE. GCDT significantly decreased the heart rate and the blood pressure in DOCA-salt induced hypertensive rats. GCDT significantly decreased the levels of aldosterone in DOCA-salt induced hypertensive rats. GCDT significantly decreased the levels of dopamine, norepinephrine, and epinephrine in DOCA-salt induced hypertensive rats. GCDT significantly decreased the levels of chloride in DOCA-salt induced hypertensive rats. These results suggest that GCDT might be effective in treatment of hypertension. |
| Key words:
Gamichungyeoldodam-tang(GCDT), Hypertension, DOCA-salt, ACE |
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