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The Journal of Internal Korean Medicine > Volume 36(3); 2015 > Article
The Journal of Internal Korean Medicine 2015;36(3): 380-390.
생쥐의 Gastrin 조절을 통한 六味地黃湯의 날문위염과 십이지장염 완화효과
정연서, 강아미, 임성우
동국대학교 한의과대학 대학원 비계내과학교실
Mitigating Effect of Yukmijihwang-tang on Antral Gastritis and Duodenitis
Yun-seo Cheong, A-mi Kang, Seong-woo Lim
Dept. of Internal Medicine, Graduate School of Oriental Medicine, Dong-Guk University
Correspondence  Seong-woo Lim ,Tel: 031-961-9043, Email: omdlsw@naver.com
Received: September 11, 2015,   Accepted: September 18, 2015,   Published online: September 30, 2015.
ABSTRACT
Objectives:
This study investigated the mitigating effect of Yukmijihwang-tang on antral gastritis and duodenitis by regulating gastrin release in mice.

Methods:
The normal group comprised mice with no inflammation; the control group comprised mice with ethanol-induced gastroduodenal inflammation. The sample group included inflammation-induced mice treated with Yukmijihwang-tang.

Results:
Based on morphology and histochemistry findings, many hemorrhagic erosions were observed in the control group, while significantly fewer erosions were seen in the sample group. Immunohistochemistry findings showed that the distributions of gastrin, substance P, HSP70, NF-κB p65, and iNOS were considerably lower in the Yukmijihwang-tang-treated group than in the control group.

Conclusions:
The findings suggest that Yukmijihwang-tang has a potent mitigating effect on antral gastritis and duodenitis
Key words: Yukmijihwang-tang, gastrin, gastritis, duodenitis
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