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The Journal of Internal Korean Medicine > Volume 29(1); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(1): 25-31.
일중음의 인체 전립선암 세포에 대한 성장억제 효과
손기정1, 박양춘2
1일중한의원
2대전대학교 한의과대학 내과학교실
Cytotoxic Effect of Iljoong-eum on Human Prostate Cancer Cells
Gi-jung Son1, Yang-chun Park2
1Il-Joong Oriental Medicine Clinic
2Dept. of Oriental Internal Medicine, College of Oriental Medicine, Daejeon University
Correspondence  Gi-jung Son ,Tel: 02-585-3600, Email: skj4426@hanmail.net
  Published online: March 30, 2008.
ABSTRACT
Objectives:
The study was intended to investigate whether Iljoong-eum (IJE) significantly affects proliferation and growth of prostate cancer cells.

Materials and Methods :
In vitro, after the treatment of DU-145 and PC-3 cells with IJE, we performed Sulforhodamine B (SRB) method. In vivo, a total of 8 male nude mice subcutaneously transplanted with the PC-3 cell line were divided in 2 groups. An experimental group was given IJE orally at a dose of 4.29ml/kg per day from the 8th to 31st day following tumor injection. All mice were observed for 31 days, and sacrificed by CO2 gas asphyxiation at the end of the experiment. The mean tumor volume and body weight of both groups were compared using Student's t-tests.

Results:
In vitro, IJE inhibited significantly proliferation and growth of DU-145 cells and PC-3 cells. In vivo, IJE inhibited significantly proliferation and growth of PC-3 cells xenografted into athymic nude mice.

Conclusions:
Our data has shown that IJE is effective in suppressing the growth rate of prostate cancer cells.
Key words: Prostate cancer, Iljoong-eum, Cytotoxic effect
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