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The Journal of Internal Korean Medicine > Volume 36(3); 2015 > Article
The Journal of Internal Korean Medicine 2015;36(3): 297-307.
녹각 추출물과 CoenzymeQ10 복합제가 운동능력에 미치는 영향
이인희1, 김민지1, 박성운1, 박여은1, 김현미2, 류재환1
Ergogenic Effect of Cervi Cornu and CoenzymeQ10 Complex
In-hee Lee1, Min-ji Kim1, Sung-woon Park1, Yeo-eun Park1, Hyun-mi Kim2, Jae-hwan Lew1
Correspondence  Jae-hwan Lew ,Tel: 02-958-1812, Email: intmed@khu.ac.kr
Received: August 20, 2015,   Accepted: September 30, 2015,   Published online: September 30, 2015.
ABSTRACT
Objectives:
We aimed to evaluate the effect of Cervi Cornu and coenzymeQ10 on exercise and endurance capacity in rats and mice.

Methods:
The extract of Cervi Cornu was manufactured by the pharmacy department of Kyung Hee Oriental Medical Hospital, and CoQ10 soft cap (Ildong Pharmaceutical) was used. In total, 24 rats and 30 mice were divided into 3 groups: Control (rat=8, mouse=10), CoQ10 alone (rat=8, mouse=10), Cervi Cornu extract, and CoQ10 (rat=8, mouse=10). Ergogenic effect was evaluated by administering the Cervi Cornu extract and coenzymeQ10 to rats and measuring the time to exhaustion during treadmill running; endurance capacity was assessed by measuring cold water swimming time, serum lactate level, and serum corticosterone level in each group. At 1 week from the end of treatment, we recalculated time to exhaustion during treadmill running in rats to investigate the long-term effect of the Cervi Cornu extract and coenzymeQ10.

Results:
Cervi Cornu extract has long-term benefits in that it preserves the ergogenic effect caused by exercise. Cervi Cornu and coenzymeQ10 have no effect on increasing cold water swimming time in ICR mice. CoenzymeQ10 decreases the serum corticosterone level in ICR mice performing cold water swimming test.

Conclusions:
Cervi Cornu seems to preserve the ergogenic effect caused by exercise, but a larger study is needed to investigate effect of Cervi Cornu and coenzymeQ10 on improving endurance capacity. CoenzymeQ10 decreases serum corticosterone level and it is related with the anti-psychological fatigue effect.
Key words: Cervi Cornu, coenzyme Q10, ergogenic effect, lactate, corticosterone
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