| 대황이 당뇨병 백서의 신장 및 혈관에 미치는 효과대황이 당뇨병 백서의 신장 및 혈관에 미치는 효과 |
| 장통영1, 남상규1, 김형구1, 김혜윤1, 이정섭1, 정현애1, 고영철2, 신선호1 |
1원광대학교 한의과대학 심계내과학교실
2삼세한방병원 내과학교실 |
| Effects of Radix et Rhizoma Rhei on the Renal Function and Vessel in the Diabetic Rats |
| Tong-young Jang1, Sang-kyu Nam1, Hyeong-gu Kim1, Hye-yoon Kim1, Jung-sup Lee1, Hyun-ae Jung1, Young-chul Ko2, Sun-ho Shin1 |
1Department of Internal Medicine, College of Oriental Medicine, WonKwang University
2SamSe Oriental Hospital |
|
|
|
Published online: December 30, 2006. |
|
|
|
| ABSTRACT |
Objectives:
This study aimed at investigating whether aqueous extract of Radix et Rhizoma Rhei (AR) ameliorates renal and vascular complications in diabetic rats.
Methods :
The experiment operated for 6 weeks. The rats were divided into 4 groups: normal group, diabetic group (control group), diabetic group treated with AR (100 mg/kg/day) for the last 3 weeks, and diabetic group treated with AR (200 mg/kg/day) for the last 3 weeks.
Results:
There were no significant changes in the renal functional parameters by treatment of AR in the diabetic rats. Aorta segment in the diabetic rats revealed a thickening of intima and media, which was ameliorated by treatment with AR. The aortic expression level of endothelin-1 was also significantly attenuated by treatment with AR.
Conclusions:
Treatment with AR could not ameliorate renal functional defects, but improved vascular complication in diabetic rats. |
| Key words:
Daibetes mellitus, Radix et Rhizoma Rhei, Endothelin |
|
PDF Links
Full text via DOI 
Download Citation 
