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The Journal of Internal Korean Medicine > Volume 27(2); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(2): 416-428.
淸肺瀉肝湯이 급성기 중풍환자의 동맥경직도 및 맥압에 미치는 영향
박영민, 홍진우, 신원준, 정동원, 김석민, 배형섭, 김영석, 조기호, 문상관, 정우상
경희대학교 한의과대학 2내과학교실
Effects of Chungpyesagan-tang on arterial stiffness and pulse pressure in acute stroke patients
Young-min Park, Jin-woo Hong, Won-jun Shin, Dong-won Jeong, Seok-min Kim, Hyung-sup Bae, Young-suk Kim, Ki-hoo Cho, Sang-kwan Moon, Woo-sang Jung
Department of Cardiovascular and Neurologic Diseases(Stroke Center), College of Oriental Medicine, Kyunghee University, Seoul, Korea
Correspondence  Ki-hoo Cho ,Tel: 02-958-9128, Fax: 02-958-9132, Email: mienie@freechal.com
Received: April 15, 2006,   Accepted: June 15, 2006,   Published online: June 30, 2006.
Arterial stiffness and pulse pressure are related to cardiovascular and cerebrovascular survival and longevity. This study is aimed at examining the effects of Chungpyesagan-tang on arterial stiffness and pulse pressure in acute stroke patients.

The subject of this study was acute strlke patients within 1 week after ictus, with Cardio-ankle vascular index(CAVI) higher than 9.0. They were divided into two groups; A treatment group (n=44) and a control group(n=46). For two weeks, Chungpyesagan-tang was given to the former, other herbal medicines to the latter. used for stroke patients for the control group for 2 weeks. At the end of first and second week, CAVI, pulse pressure, National Institute of Health stroke scale(NIHSS), Modified Barthel Index(MBI) were measured. Serum lipid profile, aspartate transaminase(AST), alanine transaminase(ALT), blood urea nitrogen(BUN), creatinine were also measured at the end of the study.

After 2 weeks, CAVI and pulse pressure in Chungpyesagan-tang group were significantly lower than those in the control group(P<0.05). NIHSS and MBI were improved in both groups. But there was no significant difference between the treatment group and the control group in terms of the NIHSS and MBI.

We suggest Chungpyesagan-tanghas desirable effects on arterial stiffness and pulse pressure of acute stroke patients. It can improve morbidity and mortality of patients on the basis of influencing vascular stiffness and increased pulse pressure.
Key words: Chungpyesagan-tang, arterial stiffness, Carotid-Ankle Vascular Index(CAVI), pulse wave velocity(PWV), pulse pressure, stroke
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