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The Journal of Internal Korean Medicine > Volume 25(2); 2004 > Article
The Journal of Internal Korean Medicine 2004;25(2): 258-267.
養生活力丹추출물이 흰쥐의 음경발기에 미치는 영향
이철호1, 윤철호1, 정지천1, 민건우2, 신현철3
1동국대학교 한의과대학 내과학교실
2자인한방병원 내과
3대구한의대학교 한의과대학 내과학교실
Effects of Yangsaengwhallyukdan extract on Erectile Function in rat
Cheol-Ho Lee1, Cheol-Ho Yoon1, Ji-Cheon Jeong1, Gun-Woo Min2, Hyeon-Cheol Shin3
1Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University
2Dept. of Internal Medicine, Jain Oriental Hospital
3Dept. of Internal Medicine, College of Oriental Medicine, Daegu Haany University
Correspondence  Ji-Cheon Jeong ,Tel: 02)3416-9731, Fax: 02)3444-9171, Email: jjcjh@hitel.net
Received: April 23, 2004,   Accepted: May 13, 2004,   Published online: June 30, 2004.
ABSTRACT
Objective :
This study investigated the effects of Yangsaengwhallyukdan on nitric oxide synthase (NOS) activity, nitrite level, antioxidation and erectile response in rat corpus cavernosum penis.

Methods :
Yangsaengwhallyukdan was formulated to contain various natural products that have been used to treat erectile dysfunction. Yangsaengwhallyukdan suspended in a 0.5% CMC solution was oral-administered, 50 mg or 100 mg per 1 kg of body weight for 30 days, while the normal group was administered only with a 0.5% CMC solution. The efficacy of the Yangsaengwhallyukdan was assessed with regard to erectile function.

Results:
After the Yangsaengwhallyukdan was administered to the rat for 30 days, the urethral NOS activity increased. The level of urethral nitrite, glutathione and testosterone increased too. The level of urethral lipid peroxide was decreased in Yangsaengwhallyukdan treated rats. The erectile response to a cavernous nerve stimulation in L-NAME(10-4)-treated rats in rats given Yangsaengwhallyukdan reached the level of the normal group.

Conclusions:
This study suggest that Yangsaengwhallyukdan is effective for the treatment of erectile dysfunction.
Key words: Yangsaengwhallyukdan, nitrite, nitric oxide synthase, glutathione, lipid peroxide, erectile function
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