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The Journal of Internal Korean Medicine > Volume 34(2); 2013 > Article
The Journal of Internal Korean Medicine 2013;34(2): 147-154.
枳朮丸 Extract가 깨어있는 흰쥐의 위 수축력에 미치는 영향
강경, 윤상협
경희대학교 한의과대학 비계내과학교실
Effect of Jichul-hwan Extract on Gastric Contractility in Conscious Rats
Kyung Kang, Sang-hyub Yoon
Dept. of Gastroenterology, College of Korean Medicine, Kyung-Hee University
Correspondence  Sang-hyub Yoon ,Tel: 02-958-9142, Email: sandrock58@nate.com
  Published online: June 30, 2013.
ABSTRACT
Objectives:
The aims of this study was to find out whether Jichul-hwan (JCH) extract has an effect on gastric contractility in conscious rats by using a force transducer implanted in the body of the stomach.

Methods :
The force transducer (model: F-081S, Starmedical, JAPAN) was implanted to the exterior wall of the stomach body in rats. The gastric contractility was measured 30 minutes before and after administration of JCH (110.1 mg/kg). The control group was administrated with normal saline instead of JCH to compare the effect of JCH. The gastric contractility of the control group (normal saline: NS) was also measured 30 minutes before and after administration of NS.

Results:
The ratio of gastric contractility between before and after medication by JCH was 1.707±0.731, and with NS was 0.701±0.541. The gastric motility increased by JCH was significantly higher than NS.

Conclusions:
JCH extract increases gastric contractility in conscious rats. We could expect that this drug would be effective in the treatment of functional dyspepsia or post-surgical gastroparesis.
Key words: Jichul-hwan, force transducer, conscious rats, gastric contractility
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