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The Journal of Internal Korean Medicine > Volume 29(1); 2008 > Article
Original Article
The Journal of Internal Korean Medicine 2008;29(1): 104-116.
淸熱膜性方이 Cationized Bovine Serum Albumin투여로 유발된 Mouse의 Membranous Nephropathy에 미치는 영향
최인구, 조충식, 김철중
대전대학교 한의과대학 신계내과학 교실
A Study on the Effects of Chungyeolmaksungbang on Mouse Model of Membranous Nephropathy Induced by Cationic Bovine Serum Albumin
In-gu Choi, Chung-sik Cho, Cheol-jung Kim
Department of Internal Medicine, College of Oriental Medicine, Daejeon University
Correspondence  Cheol-jung Kim ,Tel: 042-229-6880, Fax: 042-254-3403, Email: kidneykim@paran.com
  Published online: March 30, 2008.
ABSTRACT
Objective :
Membranous nephropathy (MN) is the most common cause of adult nephrotic syndrome worldwide. MN has been defined as granular subepithelial deposition of IgG immune complexes along the glomerular basement membrane (GBM). We aimed to identify the effects of Chungyeolmaksungbang (CYMSB) treatment on cBSA-induced in MN mouse model.

Methods :
The effect of Chungyeolmaksungbang treatment was studied on the morphology and protein excretion in the cationized bovine serum albumin (cBSA)induced mouse chronic serum sickness nephritis model. One group of mice was given intra-peritoneal (i.p.) immunizing doses of cBSA and complete Freund's adjuvant. One week later, these animals began a single i.p. injection of cBSA for 4 weeks. A second group followed the same injection protocol, but was given CYMSB p.o.

Results:
Proteinuria significantly was decreased and serum albumin was increased in the group treated with cBSA and CYMSB extract compared with the control. Serum BUN was significantly decreased on CYMSB compared with control. CD3e+/CD19 cells ratio of peripheral blood was decreased and CD4+/CD8 cells was increased. Level of IL-1β was significantly decreased, and IFN-γ was significantly increased. Concentration of IgG and IgM was significantly decreased compared with control. Thickness of GBM was decreased on histological analysis of kidney. Deposition of CD4 and CD8 was decreased on immunohistochemical staining of kidney.

Conclusions:
We conclude that CYMSB treatment may could be a useful remedy agents for treating the MN with cBSA.
Key words: cationized bovine serum albumin (cBSA), membranous nephropathy(MN), BALB/c mouse, Chungyeolmaksungbang(CYMSB)
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