| 玄參甲亢方이 Sodium Levothyroxine 투여로 유발된 백서의 |
| 장선규, 조충식, 김철중 |
| 대전대학교 한의과대학 신계내과학 교실 |
| Effects of Hyunsamkabhangbang on the Hyperthyroidism Induced by Sodium Levothyroxine in Rats |
| Sun-kyu Chang, Chung-sik Cho, Cheol-jung Kim |
| Department of Internal Medicine, College of Oriental Medicine, Daejeon University, Daejon, Korea. |
| Correspondence |
Chung-sik Cho ,Tel: 041-521-7531, Fax: 041-521-7007, Email: choo1o2@chol.com
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Published online: March 30, 2007. |
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| ABSTRACT |
Objective :
This study was to elucidate the effects of Hyunsamkabhangbang (HSK) on the hyperthyroidism induced by sodium levothyroxine.
Method:
Sprague-Dawley rats were separated into five groups. Except the normal group, the other four groups were treated with sodium levothyroxine 160㎍/㎏/day for 5 days by oral administration. Among the four groups, all except one (as control) were treated with various concentrations of HSK (0.5, 1.0, 2.0 g/㎏/days) for 3 days separately. T3-uptake, T3, T4, TSH, total cholesterol, free fatty acid, β-lipoprotein, glucose, ALP, AST, ALT change in the serum and body weight of rats were measured after medication of solid extract of HSK.
Results:
HSK decreased significantly serum T3, T4, T3-uptake, ALP, free fatty acid and glucose level in a dose-dependent manner compared with control. HSK increased significantly serum TSH and total cholesterol level and body weight in a dose-dependent manner compared with control. HSK also increased serum β-lipoprotein level compared with control, but not statistically meaningfully. HSK increased significantly serum AST and ALT level compared with control, but relationship to hyperthyroidism is not found.
Conclusions:
From these results, it could be concluded that HSK lowers excess thyroid hormone and increased metabolism, resulting in improvement of hyperthyroid state. |
| Key words:
Hyperthyroidism, HYUNSAMKABHANGBANG(HSK), Sodium levothyroxine, T3, T4, TSH. |
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