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The Journal of Internal Korean Medicine > Volume 29(1); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(1): 90-103.
消平湯이 Streptozotocin으로 유발된 당뇨쥐의 혈당 및 항산화 효소 활성에 미치는 영향
최정식1, 장선규1, 조충식1, 김철중1, 한동운2
1대전대학교 한의과대학 신계내과학교실
2천안연암대학교 동물보호과
Effects of Sopyung-tang Extract on Blood Glucose & Antioxidant Enzyme Activities ofStreptozotocin-induced Diabetic Rats
Jeong-sik Choi1, Sun-kyu Chang1, Chung-sik Cho1, Cheol-jung Kim1, Dong-un Han2
1Department of internal medicine, College of Oriental Medicine, Daejeon University
2Chonan yonam College Division of Animal Care
Correspondence  Chung-sik Cho ,Tel: 041-521-7531, Fax: 041-521-7007, Email: choo1o2@chol.com
  Published online: March 30, 2008.
ABSTRACT
Objective :
This study wascarried out to understand the effect of Sopyung-tang (SPT) on blood glucose & antioxidant enzyme activities in streptozotocin-induced diabetic rats.

Methods :
SD rats were separated into three groups, each with 20 rats. Except the normal group, the other two groups were intra-peritoneally injected with streptozotocin 60㎎/㎏. The experimental group was treated with SPT extract 500㎎/㎏ /day for 4 weeks. The normal and control groups were treated with saline 500㎎/㎏/day for 4 weeks. Changes of plasma glucose level and body weight were observed. After4 weeks, liver and kidney weight, antioxidant enzyme activities, and survival rate were observed with histological changes on liver, kidney and pancreas.

Results:
In the experimental group, body weight and survival rate increased, while plasma glucose level decreased significantly. Liver and kidney weight, XOD activity decreased in the experimental group compared to the control. GSH-px and CAT activities andinsulin-immunoreactive granules in β-cells increased significantly in the experimental group compared to the control.

Conclusions:
This study shows that SPT might be effective for treatment of diabetes and its complications, as well as reduction of oxidative stress.
Key words: Diabetes mellitus, Sopyung-tang(SPT), streptozotocin, oxidative stress, insulin-immunoreactive granules
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