| 황금이 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향 |
| 조철준, 임도희, 황지호, 양수영, 박양춘 |
| 대전대학교 한의과대학 폐계내과학교실 |
| Effect of Scutellaria Radix extract drug on immune cells and cytokines in BALF of OVA-induced asthmatic mice |
| Cheol-jun Cho, Do-hee Lim, Ji-ho Hwang, Soo-young Yang, Yang-chun Park |
| Division of Respiratory System, Dep. of Internal Medicine College of Oriental Medicine, Daejeon University, Daejeon, Korea |
| Correspondence |
Yang-chun Park ,Tel: 043-229-3704, Fax: 043-253-8757, Email: omdpyc@dju.ac.kr
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Received: February 10, 2006, Accepted: February 27, 2006, Published online: March 30, 2006. |
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| ABSTRACT |
Objective :
The purpose of this research is to examine the effects of Scutellaria Radix(SR) extract on immune cells and cytokines in ovalbumin(OVA)-induced asthmatic mice.
Methods :
In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 9 weeks. In this experiment, one group was not treated, and the other group was treated with SR extract for six weeks(five times per week) and analyzed by ELISA and flow cytometer.
Results:
In vivo, there were significant decreases in eosinophils, IL-4, IL-13 in BALF (bronchoalveolar lavage fluid) compared with that of control group. However, IFN-γ in the SR group increased significantly compared with that of control group. Additionally, the population of CD3e-/CCR3+, CD69+/CD3e+, IgE+/B220+, CD11b+/Gr-1+ cells in the SR group decreased compared with that of control group.
Conclusion:
The results of this study support a role for SR as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing INF-γ, Which helps prevent such reactions. |
| Key words:
Scutellaria Radix, asthma, cytokine. |
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