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The Journal of Internal Korean Medicine > Volume 29(3); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(3): 742-751.
三子化痰煎이 천식모델 생쥐의 면역세포에 미치는 영향
이정은, 박양춘
대전대학교 한의과대학 폐계내과학교실
Effects of Samjawhadam-jeon on Immune Cells in Ovalbumin-induced Asthmatic Mice
Joung-eun Lee, Yang-chun Park
Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University
Correspondence  Yang-chun Park ,Tel: 043-229-3704, Fax: 043-253-8757, Email: omdpyc@dju.kr
  Published online: September 30, 2008.
ABSTRACT
Objective :
The purpose of this study was to evaluate the effect of Samjawhadam-jeon (SJHDJ; 三子化痰煎) on immune cells in OVA-induced asthmatic mice.

Materials and Methods :
C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (four times a week) for asthma induction. Two experimental groups were treated with different concentrations of SJHDJ group (400 ㎎/㎏) extracts and cyclosporin A (10 ㎎/㎏) for the latter 8 weeks. At the end of the experiment, the mouse lung, peripheral lymph node (PLN) and spleen were removed and immune cells were analyzed by flow cytometer.

Results:
Lung weight, total cells in lung, PLN, and spleen of the SJHDJ group decreased significantly compared with that of the control group. Number of CD3e+/CD69+, CD3e+/DX5+ cells in lung, PLN and spleen, number of CD3+ cells in PLN and spleen, number of CD3e-/CCR3+ cells in lung and PLN, and number of B220+/IgE+ cells in PLN of the SJHDJ group decreased compared with that of the control group. Number of CD4+/CD25+ cells in PLN and spleen of the SJHDJ group increased compared with that of the control group.

Conclusion:
These results demonstrate that SJHDJ will be a desirable alternative therapy for allergic asthma by inhibiting the expression of immune cells.
Key words: Samjawhadam-jeon(三子化痰煎), asthma, immune cells
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