| 小腹逐瘀湯이 흰쥐 흉부대동맥의 혈관운동성에 미치는 영향 |
| 정용식, 권정남, 민성순, 김종득, 이상희, 김재규, 허정은, 김영균 |
| 동의대학교 부속한방병원 심계내과학 교실 |
| Effects of Water Extract of Sobokchuko-tang on Rat Blood Vessels |
| Yong-Sik Jung, Jung-Nam Kwon, Sung-Soon Min, Jong-Deuk Kim, Sang-Hee Lee, Jae-Kyu Kim, Jeong-Eun Heo, Young-Kyun Kim |
| Department of Circulatory Internal Medicine, College of Oriental Medicine, Dong-Eui University |
| Correspondence |
Young-Kyun Kim ,Tel: 051-850-8620, Fax: 051-867-5162, Email: ykkim@demc.or.kr
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Published online: September 30, 2006. |
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| ABSTRACT |
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This study was carried out to examine the relaxational response to the water extract of Sobokchuko-tang (SCT) in rat thoracic aorta. Segments of thoracic aorta obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph. It was found that the thoracic aorta segments responded to the SCT with dose-dependent vasorelaxation. At 10-7M phenylephrine-induced contraction, the contractile response of thoracic aortic rings were inhibited by 99.2%, 75.3%, 42.4% and 35.8% after addition of the respective concentration (10, 30, 100, 300㎍/㎖) of SCT. This vasorelaxation of rat thoracic aorta was endothelium-dependent. The action mechanisms of vasorelaxation are thought to be concerned with the role of NO, cAMP and cyclooxygenase, but not with cGMP. |
| Key words:
Sobokchuko-Tang (小腹逐瘀湯) |
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