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The Journal of Internal Korean Medicine 2002;23(2): 212-221. |
| 좌귀음가미방이 조혈작용에 미치는 영향 |
| 박신명, 김영철, 이장훈, 우홍정 |
| 경희대학교 한의과대학 간계내과학교실 |
| Effects of Juakium-derivative on Hematopoietic Effects |
| Shin-Myoung Park, Young-Chul Kim, Jang-Hoon Lee, Hong-Jung Woo |
| Department of Internal Medicine, College of Oriental Medicine, Kyunghee University |
| Correspondence |
Hong-Jung Woo ,Tel: 02-958-9118, Fax: 02-958-9120, Email: hjwoo@khmc.or.kr
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Received: May 20, 2002, Accepted: July 31, 2002, Published online: June 30, 2002. |
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| ABSTRACT |
Objectives:
Acording to the fact that Juakium has been frequently used in a lot of prescriptions to tonify bone marrow, We examined the hematopoietic effects of Juakium-derivative on aplastic anemia.
Methods :
After C57BL/6 mice were oral administrated with Juakium-derivative and injected with benzene, we counted the number of WBC, RBC, hemoglobin, platelet, nucleated cells and other erythroid parameters and weighed the spleen. Also we measured the expression of CD34+ cell activity and analyzed the bone marrow tissue and spleen tissue histologically.
Results:
The results are summerized as follow: 1. The Juakium-derivative plus benzene group showed the improvement in the number of WBC, RBC, hemoglobin, platelet, nucleated cells and other erythroid parameters, compared with the benzene only group. 2. The spleen weight and the percent of CD34+ cell of Juakium-derivative plus benzene group was higher, compared with the benzene only group. 3. The bone marrow tissue and spleen tissue of the Juakium-derivative plus benzene group showed the decrease of the infarcted area compared with the benzene only group.
Conclusions:
These results suggest that Juakium-derivative has hematopoietic effects on aplastic anemia induced by benzene through increasing the blood cells and stimulating the activity of CD34+ cells. Therefore it is expected that Juakiumderivative can be used clinically to the patient with hematopoietic system disorder. |
| Key words:
Juakium-derivative, aplastic anemia, hematopoietic effects |
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