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The Journal of Internal Korean Medicine > Volume 28(3); 2007 > Article
The Journal of Internal Korean Medicine 2007;28(3): 502-509.
蘇葉 추출물이 白鼠의 뇌허혈에 미치는 효과
김형우1, 김부여1, 조수진2, 정현우1, 조수인1
1동신대학교 한의과대학
2고려대학교 의과대학
Effects of Folium Perillae on Cerebral Ischemia in Rats
Hyung-woo Kim1, Bu-yeo Kim1, Su-jin Cho2, Hyun-woo Jeong1, Su-in Cho1
1College of Oriental medicine, Dongshin University
2College of medicine, Korea University
Correspondence  Su-in Cho ,Tel: 061-330-3513, Fax: 061-330-3519, Email: sicho@dsu.ac.kr
  Published online: September 30, 2007.
ABSTRACT
Objectives:
Folium perillae (FP) can relieve superficial pathogenic factors to dissipate cold and promote the circulation of qi and regulate the function of the stomach and is often used for interior qi-stagnation. We hypothesized that FP could rescue cerebral ischemia in rats.

Methods :
The present study was carried out to investigate the effects of FP on cerebral ischemia in terms of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats. Finally, lactate dehydrogenase (LDH) release was investigated, too.

Results:
In this study, treatment with FP elevated rCBF and MABP levels in dose-dependent manner. Pre-treatment with indomethacin, an inhibitor of cyclooxygenase, inhibited rCBF increase induced by FP effectively. However, FP did not affect stability during cerebral reperfusion. Finally, FP significantly inhibited LDH activity in vitro.

Conclusions:
These results suggest that FP is useful to treat patient with diseases related to cerebral ischemia, because FP can increase rCBF and MABP.
Key words: Folium Perillae; cerebral ischemia; regional cerebral blood flow; lactate dehydrogenase
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