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The Journal of Internal Korean Medicine > Volume 22(1); 2001 > Article
The Journal of Internal Korean Medicine 2001;22(1): 13-20.
小建中湯加龍骨·牡蠣가 흰쥐의 실험적 위궤양에 미치는 영향
김태중, 이윤희, 최우석, 변준석, 박순달
The Effects of Shogunjungtang-ga-younggol·morea on Gastric Ulcer
Tae-Joong Kim, Yun-Hee Lee, Woo-Seok Choi, Joon-Seok Byun, Soon-Dal Park
Department of internal Medicine, College of Oriental Medicine, Kyungsan University, Kyungbuk Korea
Correspondence  Joon-Seok Byun ,Tel: 054-450-7701, Fax: 054-450-7788, Email: jsbyun@kyungsan.ac.kr
Received: April 11, 2001,   Accepted: June 15, 2001,   Published online: March 30, 2001.
ABSTRACT
Object:
This study was carried out to examine the effects of Shogunjungtang-ga-younggol·morea on gastric ulcers.

Methods :
In order to study the effects of Shogunjungtang-ga-younggol·morea on gastric ulcers. Gastric ulcers were induced in HCl-aspirin in rats. The experiments were done by oral administration and measured by anatohistological features of ulcer lesions, and the changes of the number of parietal cells, chief cells, gastrin and somatostatin- immunoreactive cells.

Results:
In the Shogunjungtang-ga-younggol·morea administrated groups, no gross lesions of ulcer and anatohistologically, just minor injury of gastric mucosa were detected. The number of parietal cells were significantly decreased, and the number of chief cells were significantly increased, in administrated groups. The number of gastrin-immunoreactive cells and somatostatin-immunoreactive cells was significantly increased in administrated groups.

Conclusion:
According to the results, it is considered that the administration of Shogunjungtang-ga-younggol·morea seems to be applicable to the treatment of gastric ulcers.
Key words: Shogunjungtang-ga-younggol·morea, gastric ulcer, parietal cell, chief cell
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