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The Journal of Internal Korean Medicine > Volume 27(1); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(1): 276-287.
消積健脾丸顆粒이 흰쥐의 胃運動性에 미치는 영향
홍종희, 윤상협, 김진성, 류봉하
경희대학교 한의과대학 비계내과 교실
Effect of Sojukgunbihwan granule on Gastric Motility in Rats
Jong-hee Hong, Sang-hyub Yoon, Jin-sung Kim, Bong-ha Ryu
3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University
Correspondence  Sang-hyub Yoon ,Tel: 02-958-9140, Fax: 02-958-9136, Email: sandrock58@nate.com
Received: February 11, 2006,   Accepted: March 3, 2006,   Published online: March 30, 2006.
ABSTRACT
Background & Objective :
The herbal medicine Sojukgunbihwan granule has been used for the treatment of functional dyspepsia, generally categorized as a gastric dysmotility disease. However, its mechanisms are not yet well known. Therefore, the effects of Sojukgunbihwan granules on gastric motility in rats was investigated.

Methods :
The myoelectrical activity of the gastric smooth muscle was recorded by a bipolar electrode placed at the gastric antrum of rats. The contractile waves were measured for 30 minutes before and after intragastric administration of each solution(normal saline, Pyungwisan 40㎎/㎏, Sojukgunbihwan granules 60㎎/㎏) and expressed as the motility index. Gastric emptying was measured by the number of glass beads expelled from the stomach(containing one hundred 1㎜ glass beads) within an hour after glass beads and test drugs(normal saline, Pyungwisan 40㎎/㎏, Pyungwisan 120㎎/㎏, Sojukgunbihwan granules 60㎎/㎏, Sojukgunbihwan granules 180㎎/㎏) were administered. In another series of experiments to evaluate the mechanisms of Sojukgunbihwan granules under delayed conditions, the rats were treated with atropine sulfate(1㎎/㎏, s.c.), cisplatin(10㎎/㎏, i.p.), and NAME(NG-nitro-L-arginine methyl ester, 75㎎/㎏, s.c.) respectively.

Results:
Intragastric administration of Sojukgunbihwan granules increased the myoelectrical activity significantly, gastric motility index rose 25%, and gastric emptying of glass beads was significantly enhanced over a period of 60minutes. Under the delayed gastric emptying induced by atropine sulfate, cisplatin, and NAME, Sojukgunbihwan granules aggravated gastric emptying in the atropine sulfate(5.71±3.45 vs 3.71±4.42) and cisplatin(13.86±3.53 vs 5.14±5.05, p<0.01) treated groups, but enhanced gastric emptying in the NAME treated group(5.00±3.21 vs 11.71±5.65, p<0.05).

Conclusions:
Results suggest that Sojukgunbihwan granules stimulate gastric motility through cholinergic and 5-hydroxytryptamine 3 receptors. Results are indicative of Sojukgunbihwan as an especially effective remedy in dysmotility-like functional dyspepsia with impaired reservoir functions such as gastric adaptive relaxation.
Key words: Sojukgunbihwan granule, gastric motility, gastric myoelectrical activity, gastric emptying.
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