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The Journal of Internal Korean Medicine > Volume 21(4); 2000 > Article
The Journal of Internal Korean Medicine 2000;21(4): 597-604.
단삼음이 흰쥐의 소화성 궤양에 미치는 영향
Effect of the methanol extract of Dansameum on the ammonia-induced peptic ulcer in rats
Chang-Mim Jeon1, Gun-Woo Min1, Jong-Hyuck Park1, Cheol-Ho Yoon1, Ji-Cheon Jeong1, Jeong-Jun Kang2, Uk-Seob Shin3, Hyung-Jin Kim4
1Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University
2Dept. of internal Medicine, Oriental Medicine Hospital, HanSeo Univ.
3Dept. of Pharmacy, Dongguk Medical Center **, Institute of Natural Medicine, Hanseo Univ.
Correspondence  Jong-Hyuck Park ,
  Published online: November 30, 2000.
Objective :
his study was carried out to investigate the effect of Dansameum (DS) on the gastrohemorrhagic lesion induced by ammonia in rats.

Methods :
Rats were pretreated with DS extract 25 mg/kg for 10 days and then were given amonia through gastric tube. The animals were killed 1hr after amonia treatment.

DS extract siginificantly reduced the gastrohemorrhagic lesion score, the gastric lipid peroxide level, the gastric urease activity, the gastric myeloperoxidase activity, the gastric acid phosphatase activity, xanthine oxidase activity and type conversion, and increased the gastric glutathione level considerably. In photomicrographs of stomach tissue in rat, we could see the gastrohemorrhagic lesion induced clearly.

These results suggest that DS extract may be effective in peptic ulcer.
Key words: Dansameum, peptic ulcer, ammonia, urease, myeloperoxidase, glutathione
Key words: 단삼음, 소화성궤양, 암모니아, urease, myeloperoxidase, glutathione
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