| 광화학적 허혈성 뇌졸중 모델에서 瀉心湯의 뇌세포 손상 보호효과 |
| 강백규1, 윤종민1, 문병순1,2 |
1원광대학교 한의과대학 내과학교실
2원광대학교 한의학전문대학원 |
| The Protective Effects of Sasim-tang on the Brain Cell Damage in Photothrombotic
Ischemia Mouse Model |
| Baek-gyu Kang1, Jong-min Yun1, Byung-soon Moon1,2 |
1Dept. of Internal Medicine, College of Korean Medicine, Won-Kwang University
2Professional Graduate School of Korean Medicine, Won-Kwang University |
| Correspondence |
Byung-soon Moon ,Tel: 063-859-2802, Fax: 063-841-0033, Email: mbs@wku.ac.kr
|
|
|
Published online: December 30, 2012. |
|
|
|
| ABSTRACT |
Objectives:
This study was designed to investigate the effects of Sasim-tang (SST) on proinflammatory cytokine production in a photothrombotic ischemia mouse model.
Methods :
Photothrombotic ischemia was induced in stereotactically held male Balb/c mice using rose bengal (10 mg/kg) and cold light. The target of photothrombotic ischemic lesion was 1 mm anterior to bregma and 3 mm lateral to midline with 2 mm in diameter, which are decreased by oral administration of SST.
Results:
SST protected ischemic death of brain cells through inhibition of pro-inflammatory cytokines production and catalytic activation of caspase-3 protease in photothrombotic ischemia mouse model.
Conclusions:
The results of this study suggest that SST can have protective effects on brain cell damage in a photothrombotic ischemia mouse model. |
| Key words:
Sasim-tang (Xiexin-tang), photothrombotic ischemia, proinflammatory cytokine production |
|
PDF Links
Full text via DOI 
Download Citation 
