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The Journal of Internal Korean Medicine > Volume 28(2); 2007 > Article
The Journal of Internal Korean Medicine 2007;28(2): 333-345.
Mouse 유래 C2C12세포주에서 淸心蓮子湯의 심근세포 손상억제 효과
윤현덕1, 신오철1, 신유정1, 박치상1, 김승모2
1대구한의대학교 심계내과학교실
2대구한의대학교 간계내과학교실
Effect of Chungsimyeonjatang on Myocardiac Cell Injury in Mouse Myoblast C2C12 Cells
Hyeon-deok Yoon1, Oh-chul Shin1, Yoo-jeong Shin1, Chi-sang Park1, Seung-mo Kim2
1Department of Oriental Internal Medicine Daegu Haany University, Daegu, Korea
2
Correspondence  Chi-sang Park ,Tel: 053-770-2104, Fax: 053-770-2055, Email: 2nae2@hanmail.net
  Published online: June 30, 2007.
ABSTRACT
Determination and differentiation of cells in the skeletal muscle lineage is positively regulated by cell-cell contact. differentiation proteins proposed to mediate this effect include both classical MyoD and MEF members; potential interactions between the promyogenic activities of these classes of protein, however, are unknown. We show here that MyoD and MEF, two promyogenic family members that determine to each other in a cis fashion, form ineraction with MyoD- and MEF. These proteins contain myosin heavy chains and are enriched at sites of cell-cell contact between myoblasts. Therefore, In differentiation of MyoD MEF from CST (Chungsimyeonjatang) interact dependently, suggesting that the interactions occur in a cis fashion; consistent with this conclusion, MyoD-mediated differentiation is required for myoblast to occur by CST. Inhibition in myoblasts of a MyoD by STP in its ability to associate with MEF interferes with differentiation as assessed by morphological and transcription level, suggesting that this interaction is functionally important in myogenesis. Also, some of the differentiation-mediated proteins that are required for myogenesis seem to be based on interdependent activities of promyogenic classical SMAD-subfamilly.
Key words: AIF, MyoD, MEF, ROS, Chungsimyeonjatang
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