| 흰쥐의 胃 排出能에 대한 半夏瀉心湯의 效能 |
| 이준석, 윤상협, 김진성, 류봉하 |
| 경희대학교 한의과대학 비계내과학교실 |
| Effect of Banhasasimtang Granule on Gastric Emptying in Rats |
| Joonsuk Lee, Sanghyub Yoon, Jinsung Kim, Bongha Ryu |
| 3rd Deptartment of Internal Medicine, College of Oriental Medicine, Kyunghee University |
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Received: May 11, 2006, Accepted: June 16, 2006, Published online: June 30, 2006. |
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| ABSTRACT |
Backgrounds & Objectives:
Banhasasimtang granule(BHSST) has been used for the treatment of functional dyspepsia regarded as one of the gastric dysmotility disease. but its mechanisms of action are not well known yet. So we investigated the effects of BHSST on gastric emptying and its mechanisms of action in rats.
Methods:
Gastric emptying was measured by glass beads(1mm in diameter) expelled from the stomach for 60 min after administration of normal saline(NS) or BHSST 31mg/kg or 93mg/kg in rats. And by the same method gastric emptying was measured after administration of NS or BHSST 93mg/kg in rats treated with atropine sulfate(1mg/kg, s.c.), quinpirol HCl(0.3mg/kg, i.p.), NAME(NG-nitro-L-arginine methyl ester, 75mg/kg, s.c.) or cisplatin(10mg/kg, i.p.) to make delayed gastric emptying.
Results:
BHSST 93mg/kg improved gastric emptying more than NS or BHSST 31mg/kg(p=0.016). Under the delayed gastric emptying, BHSST 93mg/kg improved gastric emptying in the group treated with NAME(5.00±3.101 vs 9.00±3.51, p=0.046), but aggravated it with atropine sulfate(5.71±3.45 vs 2.57±1.62, p=0.050) and cisplatin(12.71±2.29 vs 8.57±5.06, p=0.072).
Conclusions:
BHSST improves the gastric emptying through cholinergic and 5-hydroxytryptamine 3 receptors. Especially it is effective to improve gastric emptying delayed by NAME. So we expect that it would be effective in functional dyspepsia with impaired reservoir functions such as gastric adaptive relaxation. |
| Key words:
Banhasasimtang(banxiaxiexintang), gastric emptying, functional dyspepsia |
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