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The Journal of Internal Korean Medicine > Volume 27(2); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(2): 444-458.
生津養血湯 물 추출물의 Streptozotocin 유발 고지혈증에 대한 효과
허현, 최빈혜, 김대준, 변준석
대구한의대학교 한의과대학 비계내과학교실
Hypolipemic Effect of “Saengjinyanghyul-tang” water extracts in the Streptozotocin-induced Hyperlipemic SD Rat
Hyun Hur, Bin-Hye Choi, Dae-Jun Kim, Joon-Seok Byun
3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Hanny University
Correspondence  Bin-Hye Choi ,Tel: 053-770-2081, Fax: 053-770-2169, Email: lella100@naver.com
Received: April 15, 2006,   Accepted: June 16, 2006,   Published online: June 30, 2006.
ABSTRACT
In the present study, the therapeutic hypolipemic effect of water extract of Saengjinyanghyul-tang (SJYHT), a herbal extract mixture for treatment of diabetes in oriental medicine was tested in Streptozotocin-induced diabetic hyperlipemic SD rats. For detect the therapeutic effects, the test articles were once a day dosed for 28 days by gastric gavage at a dosage 1000, 500 and 250㎎/㎏from 25 days after STZ-dosing, and the changes on body weight and gains, serum LDL, HDL, Triglyceride and Total Cholesterol levels were observed. In addition, the effects of test articles were compared to that of Simvastatin, a well known hypolipemic agents 10㎎/㎏-dosing group. Base on these results, although no meaningful effects were detected on the serum HDL levels, it is concluded that Saengjinyanghyul-tang water extracts have relatively good favorable effect treatment of STZ-induced diabetic hyperlipemia because they showed clear evidences inhibit the increase of serum LDL, Triglyceride and Total Cholesterol levels. Therefore, it is expected that Saengjinyanghyul-tang extract has favorable potency to development hypolipemic drugs. In addition, about 1000㎎/㎏ of Saengjinyanghyul-tang extracts have similar effect compared to that of Simvastatin 10㎎/㎏. The effective dosage of Saengjinyanghyul-tang water extracts in the present study was considered as below 250㎎/㎏.
Key words: Saengjinyanghyul-tang, Streptozotocin, Hyperlipemia
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