| 고지방 식이로 유발된 고지혈증 동물 모델에서 四物活血湯의 효과 연구 |
| 강성순, 신용진, 조재준, 전상윤 |
| 동신대학교 한의과대학 내과학교실 |
| Study of the Effects of Samulhwalhyeol-tang in Hyperlipidemic Animal Model
Induced with a High-Fat Diet |
| Seong-sun Kang, Yong-jin Shin, Jae-joon Jo, Sang-yun Jeon |
| Dept. of Internal Medicine, College of Korean Medicine, Dong-Shin University |
| Correspondence |
Sang-yun Jeon ,Tel: 062-350-7207, Fax: damiano70@hanmail.net,
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Published online: June 30, 2014. |
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| ABSTRACT |
Objectives:
This study was undertaken to investigate the effects of Samulhwalhyeol-tang (SM) in a hyperlipidemic animal model induced by a high-fat diet using diverse biological methods.
Methods :
This study was to determine whether fractionated EtOH extracts of SM inhibit reactive oxygen species (ROS) and nitric oxide (NO) in RAW 264.7 cells. Hyperlipidemia was induced by a high-fat diet fed for 6 weeks. Total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, glucose, liver function, cholesterol gene revelation control efficiency, and histologic change of liver were measured after oral administration of SM.
Results:
1. Compared to the control group, ROS production (%) and NO production (%) were decreased significantly by SM. 2. Total cholesterol, LDL cholesterol, triglyceride were decreased significantly by SM. 3. HDL cholesterol was increased significantly by SM. 4. Rats' body weight and glucose were decreased significantly by SM. 5. AST, ALP were decreased significantly by SM. 6. In histopathologic examination, fatty liver and fiver fibrosis were inhibited, almost eliminated as round of fat was observed in the liver.
Conclusions:
SM would appear that effective in the prevention and treatment of atherosclerosis, ischemic heart disease, other cardiovascular diseases, fatty liver and nephrotic syndrome caused by hyperlipidemia. |
| Key words:
Samulhwalhyeol-tang, hyperlipidemia, RAW 264.7 cell, C57BL/6J, antioxidant activity |
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