| 고지방 식이로 유발된 고지혈증 동물 모델에서 枸杞子加味方의 효과 연구 |
| 안가영, 조재준, 신민구, 전상윤 |
| 동신대학교 한의과대학 내과학교실 |
| Study of the Effects of Gugijagami-bang in a Hyperlipidemic Animal Model
Induced with a High-Fat Diet |
| Ga-young An, Jae-joon Joe, Min-koo Shin, Sang-yun Jeon |
| Dept. of Internal Medicine, College of Korean Medicine, Dong-Shin University |
|
|
|
Published online: December 30, 2014. |
|
|
|
| ABSTRACT |
Objectives:
This study was undertaken to investigate the effects of Gugijagami-bang (GGB) in a hyperlipidemic animal model induced by a high-fat diet using diverse biological methods.
Methods:
This study was to determine whether fractionated GGB extracts inhibit reactive oxygen species (ROS) and nitric oxide (NO) in RAW 264.7 cells. Hyperlipidemia was induced by a high-fat diet fed for 6 weeks. Total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, liver function and histologic change of liver were measured after oral administration of GGB.
Results:
1. DPPH scavenging bow performance was increased in a concentration-dependent manner by GGB. 2. Compared to the control group, NO production (%) and ROS production (%) were decreased significantly by GGB. 3. Total-cholesterol, LDL-cholesterol, triglyceride were decreased significantly by GGB. 4. HDL cholesterol increased more than the control group, but not significantly. 5. In histopathologic examination, fatty liver (hepatic steatosis) was inhibited, almost no rounds of fat were observed in the liver.
Conclusions:
GGB would appear effective in the prevention and treatment of atherosclerosis, ischemic heart disease, other cardiovascular diseases caused by hyperlipidemia. |
| Key words:
Gugijagami-bang, hyperlipidemia, RAW 264.7 cell, antioxidant activity |
|
PDF Links
Full text via DOI 
Download Citation 
