| DSS으로 유발된 생쥐의 대장점막손상에 대한 導滯湯의 효과 |
| 이주아, 공경환 |
| 세명대학교 한의과대학부속 충주병원 내과학교실 |
| Effects of Doche-tang on Colonic Mucosal Ulcer Induced by DSS in Mice |
| Ju-ah Lee, Kyung-hwan Kong |
| Department of internal Medicine, Oriental Medical Hospital of Semyung University |
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Published online: September 30, 2008. |
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| ABSTRACT |
Objectives:
This study was carried out to investigate the effects of Doche-tang on colonic mucosal ulcer induced by dextran sulfate sodium(DSS).
Method:
The group was divided into three. The normal group consisted of mice that were not inflammation-induced. The control group was composed of untreated colitis elicited mice. The sample group was administered Doche-tang after colitis elicitation. The effects on colonic mucosal ulcers were evaluated by the morphological change of colonic mucosa, the anti-oxidant effect, HSP 70, NF-κB, COX-1, COX-2 and iNOS.
Results:
In terms of immunohistochemical findings, the distribution of COX-1 in mice treated with Doche-tang noticeably increased more than that in the control group. The distribution of HSP70, NF-κB, COX-2, iNOS in mice treated with Doche-tang decreased more than that in the control group. Regeneration of surface epithelial cell and goblet cell in mucosa was observed by transmission electron microscope.
Conclusion:
According to the results, Doche-tang is practicable treatment for colonic mucosal ulcer. |
| Key words:
Doche-tang, Colonic mucosal ulcer, COX-1, COX-2, NF-κB, Dextran sulfate sodium |
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