Warning: mkdir(): Permission denied in /home/virtual/lib/view_data.php on line 87 Warning: chmod() expects exactly 2 parameters, 3 given in /home/virtual/lib/view_data.php on line 88 Warning: fopen(/home/virtual/jikm/journal/upload/ip_log/ip_log_2024-06.txt): failed to open stream: No such file or directory in /home/virtual/lib/view_data.php on line 95 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 96 The Clinical Feature of Reflux Esophagitis Patients Visiting a Single Korean Medicine Hospital: A Retrospective Study
| Home | E-Submission | Sitemap | Editorial Office |  
The Journal of Internal Korean Medicine > Volume 42(6); 2021 > Article
Lee, Choi, Lee, and Choi: The Clinical Feature of Reflux Esophagitis Patients Visiting a Single Korean Medicine Hospital: A Retrospective Study



This study investigated the clinical characteristics and symptoms of patients with reflux esophagitis (RE) visiting a Korean medicine hospital.


We retrospectively reviewed the medical records of patients with an RE diagnosis who visited a Korean medicine hospital from June 15, 2020, to April 15, 2021. We analyzed the clinical characteristics and the results of a symptoms questionnaire.


Our sample included 1,151 patients (711 females). The median age was 58 years; the most common age bracket was 60-69 years. A total of 837 patients (72.7%) presented with symptoms lasting more than one year, and 1,035 (89.9%) had been prescribed medications for more than three months before visiting a Korean medicine hospital. Belching (77.6%) and acid regurgitation (70.9%) were the most frequent symptoms, followed by epigastric pain (61.6%) and throat globus (58.5%). Throat globus was the most bothersome symptom, and 72.4% of the patients experienced the symptom on more than five days in the preceding two weeks. Patients with a longer symptom duration were older (p<0.01) and more likely to be overweight (p=0.03). Patients experiencing symptoms for more than five years were more likely to report throat globus (p=0.02), hoarseness (p<0.01), and coughing (p<0.01).


Most RE patients visiting a Korean medicine hospital were females in their sixties with chronic and refractory RE. Atypical symptoms (belching, epigastric pain, and throat globus) were common. Throat globus was highly prevalent in severe cases, suggesting that it warrants attention when treating RE patients.

I. Introduction

Gastroesophageal reflux disease (GERD) is a common and chronic disease defined as the abnormal reflux of gastric contents into the esophagus. The global pooled prevalence of GERD was approximately 13.98% and varies from 4.16% in China to 22.40% in Turkey1. Although the prevalence of GERD in Asia is lower than in Western countries, it has increased rapidly since 2000 from 13.8 to 18.3%2-4. In Korea, the number of patients who visited hospitals for GERD increased by 11.6% from 4,165,789 in 2016 to 4,650,302 in 2020, and the number of outpatients at Korean medical hospitals increased by 40.4% from 15,776 in 2016 to 22,155 in 20205.
GERD is usually diagnosed based on patient symptoms, an esophageal pH monitoring test, and gastrointestinal endoscopy. Heartburn and regurgitation are considered typical symptoms of GERD. However, atypical symptoms such as throat globus, chronic cough, and non-cardiac chest pain are prevalent in clinical practice, and can occur with or without typical symptoms6,7. GERD is classified into non-erosive reflux disease (NERD) and erosive reflux disease (ERD) or reflux esophagitis (RE) based on the detection of erosions by upper endoscopy. Although NERD is conventionally the major subcategory of GERD, its prevalence may be overestimated because a diagnosis is based on the subjective symptoms of the patient. In Korea, endoscopy has been conducted widely during regular health check-ups and it resulted in a substantial number of GERD patients being diagnosed with RE: from 3.5% in 20018 to 7.91% in 20069 and 7.1% in 200710.
GERD is conventionally treated with medications, such as PPIs and antacids and more recently, anti-reflux surgery has been suggested11. However, GERD is still regarded as a highly prevalent and frequently recurrent and refractory disorder. In clinical practice, an increasing number of symptomatic RE patients visit Korean medicine hospitals out of fear of the results of endoscopy. A previous study on the clinical spectrum of RE among Koreans undergoing health check-ups exists9, but there are no studies of RE patients seeking a traditional medicine. The aim of the present study was to investigate the clinical characteristics and symptoms of RE patients visiting a Korean medicine hospital.

II. Methods

1. Study design and Participants

A retrospective study was conducted to identify RE patients who had visited a GI clinic of Gangnam Weedahm Korean medicine hospital from June 15, 2020, to April 15, 2021. We used electronic medical records to carry out an extensive review of the patients’ medical files, including documentation of all previous medical consultations at other hospitals. In this study, we limited the sample to RE subjects who had been diagnosed on the basis of endoscopic findings. Patients were excluded if they had previously received gastrointestinal surgery, including anti-reflux surgery, or had a cancer diagnosis. The basic clinical characteristics of the patients included sex, age, body mass index (BMI), physical exercise status, eating habits, smoking status, drinking status, and status of Helicobacter pylori (H. pylori) infection. This retrospective study was approved by the Institutional Review Board of Weedahm Korean medicine hospital (WD00009-21-CR-007).

2. Assessment of symptoms

We reviewed all patient medical records and a questionnaire that was designed to assess the severity of subjective symptoms and had been administered to all patients. The questionnaire included the two most representative GERD symptoms (heartburn and regurgitation); atypical symptoms like chest pain, throat globus, hoarseness, cough, and insomnia; and some additional gastric symptoms, such as epigastric pain, belching, and hiccupping. The frequency of symptoms was determined based on symptom occurrence in the previous two weeks in the form of a five point Likert scale used in Neapen dyspepsia index12 : 0=none; 1=1-4 days; 2=5-8 days; 3=9-12 days; 4=13 or more days.

3. Outcome measures and statistical analysis

Continuous data were expressed as the mean± standard deviation. The chi-squared test and Fisher’s exact test were used to determine whether differences between groups were statistically significant. Differences between three groups were analyzed by a one-way analysis of variance. Pearson’s correlation was used to evaluate correlations between symptoms. A p-value <0.05 was considered statistically significant. All statistical analyses were performed using SPSS version 20 (IBM, USA).

III. Results

1. The baseline characteristics

A total of 1,151 patients, including 440 males (38.2%) and 711 females (61.8%), were enrolled in this study. The median age was 58.02 years, and the greatest prevalence of GERD was in the group aged 60-69 years. The mean BMI (kg/m2) was 23.5, and 626 patients (54.4%) were overweight (BMI>23). After excluding 486 patients with an unknown status of H. pylori infection, 257 patients (38.6%) were H. pylori-positive. Most patients reported that they were not current smokers or drinkers, and the percentage of current smokers was particularly low (7.4%). More than 70% of patients had suffered from subjective GERD symptoms for more than one year, and 477 patients (41.4%) reported symptoms lasting more than five years. A total of 1,035 (89.9%) patients had been treated with medications at other hospitals for more than three months before visiting a Korean medicine hospital (Table 1). Those who drink or smoke at the time of visiting a hospital were marked as ‘current drinker’ and ‘current smoker’. ‘Regular exercise’ is defined as more than 3 times a week regardless of any type of exercise, and ‘regular diet’ is defined when patient eat at the right time every day.
Table 1
Characteristics of Participating Subjects (n=1,151)
Category Value (n)
Sex (M/F) 440/711 (38.2%/61.8%)

Age (Mean±SD) 58.02±13.02
 <39 yrs (M/F) 119 (58/61)
 40-49 yrs 100 (44/56)
 50-59 yrs 330 (114/216)
 60-69 yrs 414 (158/256)
 >70 yrs 189 (66/123)

BMI (kg/m2, Mean±SD) 23.5±3.6
 < 23 525 (45.6%)
 ≥ 23 626 (54.4%)

H. pylori positive (among 665 subjects) 257 (38.6%)

Current drinker 351 (30.5%)

Current smoker 85 (7.4%)

Regular exercise 601 (52.2%)

Regular diet 716 (62.2%)

History of GERD symptoms
 <1 yr 314 (27.3%)
 1 to 5 yrs 360 (31.3%)
 >5 yrs 477 (41.4%)

Duration of treatment before vising a Korean medical hospital
 ≤3 months 116 (10.1%)
 >3 months 1035 (89.9%)

2. Prevalence of symptoms

The symptom prevalence is shown in Fig. 1. Excessive belching was the most frequent symptom and was found in 893 patients (77.6%). The next most frequent was acid regurgitation, reported by 816 patients (70.9%); epigastric pain in 709 patients (61.6%); throat globus in 673 patients (58.5%); chest pain in 643 patients (55.9%); heartburn in 600 patients (52.1%); cough in 566 patients (49.2%); and hoarseness in 389 patients (33.8%). Only 497 patients (43.2%) presented with both heartburn and acid regurgitation. Throat globus was the most bothersome symptom, considering 72.4% reported experiencing it on more than five days in the previous two weeks among those with throat globus.
Fig. 1
Presence and frequency of symptoms in previous two weeks.
The trends in symptom occurrence were similar in each age group. In terms of frequency, the general order of symptoms was belching, acid regurgitation, epigastric pain, throat globus, chest pain, heartburn, cough, insomnia, and hoarseness. However, the frequency of throat globus and chest pain was higher in patients aged 40-49 than in other age groups (Fig. 2-A). Female patients were significantly more likely than male patients to report epigastric pain (64.3%, p=0.02), belching (80%, p=0.01), throat globus (61%, p=0.03), and insomnia (49.9%, p<0.01)(Fig. 2-B).
Fig. 2
Presence of symptoms according to (A) age and (B) gender.
The coexistence of majority of atypical symptoms was higher in patients with typical symptoms (Table 2). However, the insomnia comorbidity rate was higher in the group without typical symptoms. Furthermore, the frequency of atypical symptoms in this study compared to previous studies is shown in Table 3.
Table 2
Frequency of Atypical Symptoms according to Existence of Two Typical Symptoms
Symptoms Heartburn exist group (n=600) Acid regurgitation exist group (n=816) None of typical symptoms group (n=232)
Epigastric pain 445 (74.2%) 537 (65.8%) 94 (40.5%)
Belch 493 (55.2%) 674 (82.6%) 147 (63.4%)
Chest pain 420 (70.0%) 496 (60.8%) 81 (34.9%)
Throat globus 400 (66.7%) 511 (62.6%) 103 (44.4%)
Hoarseness 236 (39.3%) 299 (36.6%) 62 (26.7%)
Cough 347 (57.8%) 438 (53.7%) 78 (33.6%)
Insomnia 284 (58.3%) 360 (44.1%) 156 (67.2%)
Table 3
Frequency of Atypical Symptoms in Various Studies
Study The present study Yi et al.13 (2012) Cho et al.8 (2005)
Country, target population Korea, Patient visiting a single KM hospital Taiwan, Patient visiting a single GI clinic Korea, Population based study
Participants RE n=1,151 GERD n=210 (ERD, n=90+NERD, n=120) Frequent GERD* n=50 among 1,417 subjects

Atypical symptoms
 Chest pain 54.5% 50.5% 44.0%
 Throat globus 52.2% 36.7% 14.0%
 Cough 40.8% 22.1% -
 Belch 80.6% 54.6% -
 Hoarseness 26.1% - 10.0%
 Dysphagia - 27.6% 16.0%
 Extra symptoms Epigastric pain 65.3%
Arrhythmia 9.6%
Insomnia 43.6%
Dyspepsia 52.9%
Hiccup 55.1%
Asthma 26.0%
Bronchitis 20.0%

ERD : erosive reflux disease, KM : Korean medicine, NERD : non-erosive reflux disease,

* At least weekly symptoms

3. Differences among groups divided by duration of subjective symptoms

There were no significant differences in the characteristics (age, sex, BMI, alcohol/smoking habit, physical exercise status, and eating habits) or subjective symptoms of patients who had been treated for more than three months (n=1,035) versus less than three months (n=116) before visiting a Korean medicine hospital (data not shown). The only significant differences in the characteristics of three groups divided by duration of subjective symptoms were sex, BMI, and age (Table 3). Patients with a longer duration of symptoms tended to be older (p<0.01) and were more likely to be overweight (p=0.03). Throat globus (p=0.02), hoarseness (p<0.01), and cough (p<0.01) were more common in patients suffering more than five years compared to patients with a shorter duration of symptoms (Table 4, Fig. 3). In addition, a slightly higher percentage of patients with symptoms lasting more than five years had an arrhythmia (14.5% vs. 12.3% of the overall sample), but without statistically significant (p=0.12).
Table 4
Characteristics and the Presence of Symptoms according to Symptom Duration
Duration of symptoms ≤1 year (N=314) 1<Duration of symptoms <5 (N=360) Duration of symptoms ≥5 years (N=477) p-value
No of males (%) 33.1 47.2 34.8 0.00**
Overweight patient (%) 49.0 54.9 54.1 0.03*
Mean age 56.32 56.81 60.01 0.00**
H. pylori positive (%) 22.6 19.7 24.1 0.49
Current smoker (%) 6.4 8.3 7.3 0.62
Current drinker (%) 26.1 33.9 30.8 0.09
Regular exercise (%) 51.0 55.0 50.7 0.42
Regular diet (%) 62.1 64.2 60.6 0.57

 Heartburn (%) 48.7 54.7 52.4 0.30
 Acid regurgitation (%) 68.8 69.2 73.6 0.24
 Epigastric pain (%) 65.3 58.3 61.6 0.18
 Belch (%) 80.6 75.3 77.4 0.26
 Chest pain (%) 54.5 57.8 55.3 0.66
 Throat globus (%) 52.2 62.5 59.5 0.02*
 Hoarseness (%) 26.1 36.7 36.7 0.00**
 Cough (%) 40.8 51.4 53.0 0.00**
 Arrhythmia (%) 9.6 11.9 14.5 0.12
 Insomnia (%) 43.6 39.2 43.8 0.35

Analyzed by chai-square test and Fisher’s exact corrections,

* p-value<0.05,

** p-vale<0.001

Fig. 3
Different proportions of symptoms among groups divided by duration of symptoms.

IV. Discussion

This study describes the characteristics of RE patients visiting a single Korean medicine hospital. The patients were predominantly female (61.8%) and the 60-69 year age range was the most common, compared to the previous studies reported that males were more prevalent3,9,13 and that patients were evenly distributed by age9,13. Findings of the present study reflect the preference of women and older people for Korean medicine.
In this study, 72.7% of patients visited a Korean medicine hospital for symptoms lasting more than one year and 89.9% of patients had been prescribed PPIs, H2 blockers, or other medications for more than three months. This is consistent with the gradual increase in Korea in the use of PPIs for at least three months and 10% of patients were prescribed more than the standard dose, with a significant economic burden14. Furthermore, these findings show that the majority of patients visiting a Korean medicine hospital are experiencing chronic RE that is refractory to conventional treatment.
Trends in symptom frequency were similar across age groups, but throat globus and chest pain were relatively higher in patients aged 40-49 years compared to other age groups. Most symptoms were more frequently reported by females than by males, probably because of differential symptom perception by sex (as in Kim et al.15). Notably, 49.9% of female patients had insomnia versus 30% of male patients. A previous study reported that insomnia in GERD patients was not affected by sex, but by the severity of extra-esophageal symptoms16. The higher proportion of female insomnia patients in this study could be affected by the frequency of atypical symptoms in females. Of the characteristics that we examined in the present study, which included BMI, alcohol, tobacco, physical exercise, and dietary habits, only BMI was correlated to duration of symptoms. A higher proportion of overweight patients was reported in groups with symptoms lasting more than five years, indicating that it is necessary to consider the need for weight control in long-term treatment of GERD. In contrast to a previous study finding that H. pylori infection may be negatively associated with GERD9,17, the present study found no relationship between H. pylori infection and GERD, which is probably attributable to a lack of data.
GERD patients are reported to present with a broad range of troublesome symptoms. In the present study, 70.9% and 52.1% of RE patients presented with acid regurgitation and heartburn, respectively. Only 43.2% of patients presented with both symptoms. This percentage is far smaller than that reported in previous studies finding that typical symptoms were reported by 60-68% of patients in western countries18 and 60% of patients in Japan4. However, it is higher than the percentage reported in a previous Korean study that found that 33.3% of RE patients presented with heartburn and 35.6% with acid regurgitation9.
It is well-known that atypical symptoms are highly prevalent and found in up to 80% of patients19. Atypical symptoms were reported to be highly frequent and bothersome in the present study. Excessive belching was the most frequent symptom and was reported by 77.6% of all subjects. This is consistent with the recent studies that have increased awareness of the association between excessive supragastric belching and GERD, and of the fact that excessive belching may even be attributable to PPI-refractory GERD20,21. Moreover, epigastric pain, throat globus, and chest pain were found more frequently than heartburn. This is supported by a study of 25,536 people undergoing health check-ups in Korea, which found that epigastric soreness was the most frequent symptom in RE9. Tack et al.22 also found that epigastric pain was found mainly in patients with pathological acid exposure, and Cho et al.8 suggested it was probable that Korean patients would complain of epigastric soreness or chest pain (i.e., heartburn).
Another notable finding in this study was the importance of throat globus in GERD. ‘Throat globus’ means a non-painful sensation of a lump or foreign body in the throat. 58.5% of all patients presented with throat globus. This is higher than the percentages reported in other studies, which range from 14.0-55.2%8 or 22.8%9 in Korea and 36.7% in Taiwan23. Furthermore, this symptom is relatively severe; 72.4% of patients presenting with throat globus experienced the symptom on more than five days in the previous two weeks, and patients with a longer duration of symptoms were more likely to report throat globus, hoarseness, cough, and arrhythmia. Throat globus in GERD can be explained by two mechanisms: direct irritation or inflammation of the laryngopharynx caused by gastric contents and vagovagal reflux triggered by acidification24. Thus, it is necessary to assess throat globus as it can be an indicator of the severity of RE and affect treatment decisions.
In addition, we suggest consideration of the cardiovascular aspect of GERD. This is appropriate given that 12.3% of patients in the present study had an arrhythmia, which is similar to the reported incidence of atrial fibrillation, 0.62% to 14%, in GERD patients25. The incidence of an arrhythmia was increased in patients with a longer duration of symptoms. The vagovagal reflux triggered by acidification may cause an arrhythmia as well as throat globus24. This can also be understood by referring to the conceptualization of GERD in Korean medicine, where it is addressed by treating ‘stomach or spleen’ and ‘heart’, as with the medication ‘Ban Xia Xie Xin Tang’26.
This study is meaningful in that it analyzed the clinical features of more than 1,000 RE patients who visited a Korean medicine hospital, which will be different from population-based studies or studies on patients visiting the conventional treatment. In addition, the characteristics of atypical symptoms of GERD that can be overlooked in conventional treatment were analyzed. Since most of RE patients are accompanied by atypical symptoms, it is thought that Korean medicine treatment that comprehensively considers these will be better in treating GERD patients than medications such as PPIs.
This study has several limitations. Detailed data on the endoscopic classification (such as Los Angeles classification of GERD) and types of medication taken, such as PPI or prokinetic drugs, are lacking. In addition, a certified questionnaire was not used for evaluating the severity of symptoms. As coffee consumption can affect the development of GERD27, the consumption of coffee is recommended in further study.
Therefore, further study with information about medication patient used, consumption of coffee or tea, herbal prescriptions, and the rate of improvement with herbal medicine will be needed. Also, additional study with annual data involving both NERD and RE patients evaluated with verified questionnaires is required.

V. Conclusion

In conclusion, the present study shows that patients visiting a hospital for Korean medicine were predominantly females in their sixties with chronic and refractory RE. Female patients tended to have more frequent symptoms and patients aged 40-49 years had a higher prevalence of throat globus and chest pain compared to other age groups. Atypical symptoms, such as belching, epigastric pain, and throat globus, were frequent. Throat globus was particularly prevalent in severe cases, suggesting that the symptom merits careful attention when treating GERD patients.


Ethical statement

This research was reviewed and approved by the institutional review board of Weedahm Korean medicine hospital (WD00009-21-CR-007). Informed consent was obtained from all participants.


1. Nirwan JS, Hasan SS, Babar ZUD, Conway BR, Ghori MU. Global Prevalence and Risk Factors of Gastro-oesophageal Reflux Disease (GORD):Systematic Review with Meta-analysis. Sci Reports 2020:10(1):1–14.

2. Inamori M, Togawa JI, Nagase H, Abe Y, Umezawa T, Nakajima A, et al. Clinical characteristics of Japanese reflux esophagitis patients as determined by Los Angeles classification. J Gastroenterol Hepatol 2003:18(2):172–6.
crossref pmid
3. Rosaida MS, Goh KL. Gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population:A prospective, endoscopy based study. Eur J Gastroenterol Hepatol 2004:16(5):495–501.
crossref pmid
4. Okamoto K, Iwakiri R, Mori M, Hara M, Oda K, Danjo A, et al. Clinical Symptoms in Endoscopic Reflux Esophagitis:Evaluation in 8031 Adult Subjects. Dig Dis Sci 2003:48(12):2237–41.
crossref pmid
6. Vaezi MF, Katzka D, Zerbib F. Extraesophageal Symptoms and Diseases Attributed to GERD:Where is the Pendulum Swinging Now? Clin Gastroenterol Hepatol 2018:16(7):1018–29.
7. Zerbib F, Dulery C. Facts and Fantasies on Extraesophageal Reflux:A Gastroenterologist Perspective. J Clin Gastroenterol 2017:51(9):769–76.
8. Cho YS, Choi MG, Jeong JJ, Chung WC, Lee IS, Kim SW, et al. Prevalence and clinical spectrum of gastroesophageal reflux:A population-based study in Asan-si, Korea. Am J Gastroenterol 2005:100(4):747–53.
9. Shim KN, Hong SJ, Sung JK, Park KS, Kim SE, Park HS, et al. Clinical spectrum of reflux esophagitis among 25,536 Koreans who underwent a health check-up:a nationwide multicenter prospective, endoscopy-based study. J Clin Gastroenterol 2009:43(7):632–8.
10. Yang SY, Lee OY, Bak YT, Jun DW, Lee SP, Lee SH, et al. Prevalence of gastroesophageal reflux disease symptoms and uninvestigated dyspepsia in Korea:a population-based study. Dig Dis Sci 2008:53(1):188–93.
crossref pmid
11. Park S, Park S, Park JM, Ryu S, Hwang J, Kwon JW, et al. Anti-reflux surgery versus proton pump inhibitors for severe gastroesophageal reflux disease:A cost-effectiveness study in Korea. J Neurogastroenterol Motil 2020:26(2):215–23.
crossref pmid pmc
12. Talley NJ, Haque M, Wyeth JW, Stace NH, Tytgat GN, Stanghellini V, et al. Development of a new dyspepsia impact scale:The Nepean Dyspepsia Index. Aliment Pharmacol Ther 1999:13(2):225–35.
13. Chang CS, Poon SK, Lien HC, Chen GH. The Incidence of Reflux Esophagitis among the Chinese. Am J Gastroenterol 1997:92(4):668–71.
14. Park S, Kwon JW, Park JM, Park S, Seo KW. Treatment pattern and economic burden of refractory gastroesophageal reflux disease patients in Korea. J Neurogastroenterol Motil 2020:26(2):281–8.
crossref pmid pmc
15. Kim YS, Kim N, Kim GH. Sex and Gender Differences in Gastroesophageal Reflux Disease. J Neurogastroenterol Motil 2016:22(4):575.
crossref pmid pmc
16. Choi JY, Jung HK, Roh SH, Tae CH, Kim SE, Shim KN, et al. Sleep Disorder Associated with Gastroesophageal Reflux Disease. Korean J Med 2011:81(5):602–10.

17. El-Serag H, Sonnenberg A. Opposing time trends of peptic ulcer and reflux disease. Gut 1998:43(3):327.
crossref pmid pmc
18. Klauser AG, Schindlbeck NE, Müller-Lissner SA. Symptoms in gastro-oesophageal reflux disease. Lancet(London, England) 1990:335(8683):205–8.
crossref pmid
19. Locke GR 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd. Prevalence and clinical spectrum of gastroesophageal reflux:a population -based study in Olmsted County, Minnesota. Gastroenterology 1997:112(5):1448–56.
crossref pmid
20. Sawada A, Fujiwara Y, Sifrim D. Belching in Gastroesophageal Reflux Disease:Literature Review. J Clin Med 2020:9(10):3360.
21. Koukias N, Woodland P, Yazaki E, Sifrim D. Supragastric Belching:Prevalence and Association With Gastroesophageal Reflux Disease and Esophageal Hypomotility. J Neurogastroenterol Motil 2015:21(3):398–403.
crossref pmid pmc
22. Tack J, Caenepeel P, Arts J, Lee KJ, Sifrim D, Janssens J. Prevalence of acid reflux in functional dyspepsia and its association with symptom profile. Gut 2005:54(10):1370.
crossref pmid pmc
23. Yi CH, Liu TT, Chen CL. Atypical symptoms in patients with gastroesophageal reflux disease. J Neurogastroenterol Motil 2012:18(3):278–83.
crossref pmid pmc
24. Lee BE, Kim GH. Globus pharyngeus:A review of its etiology, diagnosis and treatment. World J Gastroenterol 2012:18(20):2462–71.
pmid pmc
25. Roman C, Des Varannes SB, Muresan L, Picos A, Dumitrascu DL. Atrial fibrillation in patients with gastroesophageal reflux disease:A comprehensive review. World J Gastroenterol 2014:20(28):9592–9.
pmid pmc
26. Gan Y, Liu H, Yang L, Yang K. Effect of banxiaxiexin tang on treatment of functional dyspepsia:a meta-analysis of randomized controlled trials. J Tradit Chinese Med =Chung i tsa chih ying wen pan 2014:34(2):140–4.

27. Mehta RS, Song M, Staller K, Chan AT. Association Between Beverage Intake and Incidence of Gastroesophageal Reflux Symptoms. Clin Gastroenterol Hepatol 2020:18(10):2226–33.
crossref pmid
Editorial Office
Dongguk University Ilsan Oriental Hospital
27, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326 Korea
TEL: +82-31-961-9046   FAX: +82-31-961-9049   E-mail: jikm.edit@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Society of Internal Korean Medicine.                 Developed in M2PI      |      Admin Login