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The Journal of Internal Korean Medicine > Volume 42(5); 2021 > Article
The Journal of Internal Korean Medicine 2021;42(5): 1082-1093.
doi: https://doi.org/10.22246/jikm.2021.42.5.1082
구기지황탕 투여 후 호전된 경도인지장애 환자 1례에 대한 증례보고
박미소1,2, 강석만3, 유대원3, 채인철1,2, 김경순3, 성현주3, 정광렬3, 유호룡1,2
1대전대학교 한의학과 심계내과학교실
2대전대학교 대전한방병원 임상시험센터
A Case Report of a Patient with Mild Cognitive Impairment Treated with Gugijihwang-tang
Mi-so Park1,2, Seock-man Kang3, Dai-won Yoo3, In-cheol Chae1,2, Gyeong-soon Kim3, Hyun-joo Seong3, Kwang-yeol Chung3, Ho-ryong Yoo1,2
1Dept. of Cardiology and Neurology of Korean Medicine, College of Korean Medicine, Daejeon University
2Clinical Trial Center, Daejeon Korean Medicine Hospital of Daejeon University
3MyungMin Korean Medicine Clinic
Correspondence  Ho-ryong Yoo ,Tel: +82-42-470-9131, Fax: +82-42-470-9005, Email: hryoo@dju.kr
Received: September 17, 2021,   Accepted: November 1, 2021,   Published online: October 30, 2021.
Alzheimer's disease is characterized by progressive, irreversible brain damage and cognitive decline. Although the diagnosis and treatment of the prodromal symptoms of dementia are important, no treatment for mild cognitive impairment has been currently established. Herein, we report the case of an 80-year-old female patient with memory complaints treated with Gugijihwang-tang, a traditional Korean medicine herbal formula, as an add-on medication.

Case Presentation:
The patient was diagnosed with mild cognitive impairment based on clinical examinations using the Mini-Mental State Examination (MMSE), the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Activities of Daily Living (ADL) Scale, Global Deterioration (GDR) Scale, and Clinical Dementia Rating (CDR) Scale. She was treated with Gugijihwang-tang bis in die for 12 months while continuing her original medications, including 5-mg donepezil and 590-mg acetyl-l-carnitine. The MMSE score in the Korean Version of the CERAD Assessment Packet increased from 21 to 27 during the 12-month treatment period, and the CERAD 2 score increased from 33 to 62. The instrumental ADL scale score improved from 11 to 5. Other clinical examination results also showed improvement. The patient was satisfied and experienced no significant adverse events related to the Gugijihwang-tang treatment.

This case suggests that Gugijihwang-tang could be considered as a treatment method for patients with mild cognitive impairment.
Key words: Korean medicine, herbal medicine, Gugijihwang-tang, case report, mild cognitive impairment
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