| 半夏白朮天麻湯이 Doxorubicin에 의해 誘發된 毒性에 미치는 影響 |
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| Effect of Banhabakchulchunma-tang on the Hepatic, Splenic and Cardiac Toxicity induced by Doxorubicin |
| Hui-Jeung Hwang, Bong-Suk kim, Jung-Han Oh, Hee-Yong Lim, Jung-Han Beak, Chi-Sang Park, Sang-Chan Kim, Joon-Seok Byun |
1Department of Internal Medicine, College of Oriental Medicine, Kyungsan University, Daegu, Korea
2Department of Pediatrics, College of Oriental Medicine, Kyungsan University, Daegu, Korea
3Department of Formulae Pharmacology, College of Oriental Medicine, Kyungsan University, Daegu, Korea |
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Received: January 30, 2003, Accepted: March 10, 2003, Published online: June 30, 2003. |
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| ABSTRACT |
Object:
The effect of Banhabakchulchunma-tang extracts on the hepatic, splenic and cardiac toxicity induced by Doxorubicin administration(Three injection protocol) were monitored using male ICR mice.
Methods :
The changes of body weight, clinical signs, necropsy findings and organ weights of liver, spleen and heart were observed with blood GOT and GPT levels.
Results:
1. Decrease of body weight and The degrees of anorexia, ataxia and dehydration after Doxorubicin treatment were dosedependently inhibited by Banhabakchulchunma-tang extracts. 2. Increase of absolute and relative liver and heart weight observed in Doxorubicin treatment group were dose-dependently inhibited by Banhabakchulchunma-tang extracts. In addition, the degrees of liver congestion necrotic spot and the degrees of heart congestion enlargement were dose-dependently decreased after Banhabakchulchunma-tang extracts dosing groups compared to that of doxorubicin treatment group. It is also demonstrated that elevated serum GOT and GPT levels in doxorubicin treatment group were significantly decreased in Banhabakchulchunma-tang extracts dosing groups. 3. Decrease of absolute and relative spleen weight observed in doxorubicin treatment group were dose-dependently inhibited by Banhabakchulchunma-tang extracts. In addition, the degrees of splenic atrophy were significantly and dosedependently decreased after Banhabakchulchunma-tang extracts dosing groups compared to that of doxorubicin treatment group.
Conclusion:
the toxicity of doxorubicin treatment(decrease of body weights, clinical signs such as anorexia, ataxia and dehydration, changes of organ weights of liver, spleen and heart, elevation of serum GOT and GPT levels) was inhibited and/or prevented by Banhabakchulchunma-tang extracts. According to these results, it is considered that Banhabakchulchunma-tang has some preventive effect against to doxorubicin induced toxicity. |
| Key words:
Banhabakchulchunma-tang, Doxorubicin, Toxidity |
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