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The Journal of Internal Korean Medicine > Volume 21(5); 2000 > Article
The Journal of Internal Korean Medicine 2000;21(5): 869-872.
뇌경색 한방치료 중 독성간염(약물유인성 간염)으로 추정되는 간기능 손상의 1례
이승희, 이민수, 송미덕
혜당한방병원
One Case of The Hepatic Injury Suggested Toxic Hepatitis(Drug Induced Hepatatis) in the Treatment of Oriental Medicine for Cerebral Infarction
Seung-Hi Lee, Min-Su Lee, Mi-Deok Song
Hae Dang Oriental Medical Hospital
Correspondence  Seung-Hi Lee ,
  Published online: December 30, 2000.
ABSTRACT
Although there are a few reports concerning the hepatic injury of herbal medicine in western medicine, there is no reports concerning the hepatic injury of herbal medicine in oriental medicine. We experienced one case of the hepatic injury suggested toxic hepatitis (drug induced hepatitis) in the treatment of oriental medicine for cerebral infarction. We make a reports for the progress of treatment. One patient of Rt hemiparesis diagnosed cerebral infarction in Brain MRI was administered Taeumin Yuldahanso-tang, treated with physical therapy and improved in the state of Rt hemiparesis(Gr 2/3,4). In the course of treatment, the patient intermittently complained of general weakness, dizziness, pericephalic discomfort, nausea, both leg weakness so we changed Taeumin Yuldahanso-tang to Soyangin Dokwhaljiwhang-tang. After that, the patient complained of general weakness, abdominal discomfort, heat and fever(38.4℃). We recognized the elevated total bilirubin(1.7mg/dl), serum transaminase(AST534U/L ALT720U/L), serum gammg glutamyl transpepridase (GGT106mg/dl) and Alk phosphatase124U/L. In the abdominal ultrasonogram there is hepatomegaly (16.5cm). We supposed hepatic injury suggested toxic hepatitis(induced hepatitis) of herbal medicine. After we administered Saeng gan gunbi-tang for 2days and Alk phosphatase and GGT inadequately was elevated. After that, we stopped administering medicine and the serum transaminase, total bilirubin, serum gamma glutamyl transpeptidase and Alk phosphatase level was decreased. In the abdominal ultrasonogram there was no signal. In the case, we supposed that the changing Sasang constitution and Sasang herbal medicine may induce hepatic injury. We are suggesting the necessity of a test for the hepatic injury of herbal medicine.
Key words: Hepatic injury, Herbal medicine.
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