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The Journal of Internal Korean Medicine 2002;23(3): 364-374. |
| 시박탕및 팔미지황탕이 Puromycin Amininucleoside 로 유발된 백서의 신증에 미치는 영향 |
| 황상호, 안영민, 안세영, 두호경 |
| 경희대학교 한의과대학 신계내과학교실 |
| The Effects of Sibaktang(Chaipotang) and Palmijihwangtang (Baweidihuangtang) on Rats with Nephrosis Induced by Puromycin Aminonucleoside |
| Sang Ho Hwang, Young-Min Ahn, Se-Young Ahn, Ho-Kyung Doo |
| Department of 6th Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea |
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Received: July 19, 2002, Accepted: August 31, 2002, Published online: September 30, 2002. |
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| ABSTRACT |
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The nephrotic syndrome is characterized by proteinuria, hypoalbuminemia, hyperlipidemia, and edema. In this study, we were to assess the effects of Sibaktang and Palmijihwangtang on rats with nephrotic syndrome induced by a single intravenous injection of puromycin aminonucleoside(PAN), 2.5 mg/100g of body weight. The effects were evaluated by measuring the levels of albumin, total protein, total lipid, cholesterol, triglyceride, creatinine, blood urea nitrogen, uric acid in the serum, and the levels of protein, glucose, creatinine in the urine. The changes of microscopic findings of glomeruli were also observed. The results are summarized as follows; 1. Sibaktang group should the significant effects of decreasing the volume of proteinuria and increasing the levels of albumin, and total protein in the serum. Furthermore it had the significant effects of decreasing the levels of cholesterol, total lipids, and triglycerides in the serum and glucose in the urine. Electron microscopic findings were the segmental obliterations of the foot processes, swelling of the visceral epithelial cells and partial increase of the mesangial matrix. 2. Palmijihwangtang group should the significant effects of decreasing the volume of proteinuria and increasing the levels of albumin, and total protein in the serum. Furthermore, it should the significant effects of decreasing the levels of cholesterol, total lipids, triglycerides and uric acid in the serum and glucose in the urine. Electron microscopic findings were similar to those of Sibaktang group. Therefore, we could conclude that Sibaktang and Palmijihwangtang may have effects of relieving proteinuria, hypoalbuminemia, hyperlipidemia and glycosuria in nephrotic syndrome. But comparing Sibaktang and Palmijihwangtang to the Control, there was no significant difference in electron microscopic findings. However, there should be further studies of the effects on the alterations of glomerular polyanion sites, and on the functioning mechanism of both prescriptions. |
| Key words:
The nephrotic syndrome, Sibaktang, Palmijihwangtang, Puromycin Aminonucleoside |
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