|
|
The Journal of Internal Korean Medicine 2001;22(1): 5-11. |
| 黃連解毒湯의 前投與가 CCL4와 ethanol 中毒흰쥐의 肝臟 및 腎臟에 미치는 組織病理學的 硏究 |
| 윤주현, 김승모, 임명현, 박재현 |
| 경산대학교 한의학과 간계 내과학 교실 |
| A Histological Study of the effects of CCL4 and Ethanol on the Liver and Kidneys of Rats after Preadministration of Hwangryunhaedoktang |
| Ju-Hyun Yoon, Seong-Mo Kim, Myung-Hyun Leem, Jae-Hyun Park |
| Department of internal Medicine, College of Oriental Medicine, Kyungsan University, Kyungbuk Korea |
| Correspondence |
Jae-Hyun Park ,Tel: 053-770-2101, Fax: 053-764-0566, Email: jhpark@ksucc.ac.kr
|
|
|
Received: March 14, 2001, Accepted: June 1, 2001, Published online: March 30, 2001. |
|
|
|
| ABSTRACT |
Object:
This study was carried out to examine the effect of Hwangryunhaedoktang on the liver and kidney of rats induced by carbon tetrachloride and ethanol.
Methods :
The histopathological changes were examined after preadministration of 100 and 200㎎/100g Hwangryunhaedoktang.
Results:
The perivenular ballooning degeneration and infiltration of basophilic inflammatory cells were decreased in the experimental group when compared with the control group. No abnormalities were observed in the kidneys of both groups. But, interstitial nephritis was observed only in the experimental group.
Conclusion:
This study suggests that Hwangryunhaedoktang may be of benefit to the prevention of hepatotoxicity induced by carbon tetrachloride and ethanol, and it is more effective in high dosages. |
| Key words:
Hwangryunhaedoktang, carbon tetrachloride, ethanol. |
|
|
|
PDF Links
Full text via DOI 
Download Citation 
