Effect of Heating Condition and Panax Ginseng
on Body Temperature, Hematological Changes, and Immune Response in Rat

Yi, Seo-ra; Lee, In-hee; Kim, Min-ji; Lew, Jae-hwan

The Journal of Internal Korean Medicine > Volume 35(1); 2014 > Article

Original Article

The Journal of Internal Korean Medicine 2014;35(1): 59-69.

온열환경과 인삼(Panax Ginseng)이 Rat의 체온, 혈액학적 변화, 면역반응에 미치는 영향

이서라¹, 이인희¹, 김민지¹, 류재환²

¹경희대학교 한의과대학 내과학교실
²경희대학교 동서의학대학원 동서의학과

Effect of Heating Condition and Panax Ginseng on Body Temperature, Hematological Changes, and Immune Response in Rat

Seo-ra Yi¹, In-hee Lee¹, Min-ji Kim¹, Jae-hwan Lew²

¹Dept. of Oriental Internal Medicine, College of Oriental Medicine, Kyung-Hee University
²East-west Medicine Department, Graduate School of East-west Medical Science, Kyung-Hee University

Correspondence

Jae-hwan Lew ,Tel: 02-958-1812, Fax: 02-958-9212, Email: intmed@khu.ac.kr

Published online: March 30, 2014.

ABSTRACT

Objectives:
This study was designed to test the effect of heating condition and Panax ginseng on body temperature, hematologicala changes, and immune response.

Methods :
The extract from Panax ginseng was made by the pharmacy department of Kyung Hee Oriental Medical Hospital. The animals were divided into four groups; control, room temperature Panax ginseng (G), 28 ℃ heating, and 28 ℃ heating Panax ginseng (heating G). Each group has 8 Sprague-Dawley rats. We measured body weight & temperature twice a week. After 2 weeks of experiment, serum lipid level, WBC, differential count, lymphocyte proliferation and immune cytokine concentration were measured.

Results:
1. Simultaneous application of heating condition and Panax ginseng induced decreased body weight and increased body temperature. 2. Simultaneous application of heating condition and Panax ginseng induced decreased AST, ALT and BUN. 3. Simultaneous application of heating condition and Panax ginseng tended to decrease TNF-α concentration, while application of room temperature and Panax ginseng tended to increase TNF-α concentration.

Conclusions:
Simultaneous application of heating condition and Panax ginseng decreseas body weight, increases, body temperature and has a tendency to decrease TNF-α concentration.

Key words: heating, Panax ginseng, body weight, body temperature, immune, TNF-α