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The Journal of Internal Korean Medicine 2013;34(4): 384-404. |
| 보기제통탕이 말초신경병증 모델에서 신경 손상 회복에 미치는 영향 |
| 박상우, 김철중, 조충식 |
| 대전대학교 한의과대학 신계내과학교실 |
| Effects of Nerve Regeneration by Bogijetong-tang Treatment on Peripheral Nerves
Damaged by Taxol and Crush Injury |
| Sang-woo Park, Chul-jung Kim, Chung-sik Cho |
| Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University |
| Correspondence |
Chung-sik Cho ,Tel: 041-521-7531, Fax: 041-521-7007, Email: choo1o2@dju.kr
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Published online: December 3, 2013. |
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| ABSTRACT |
Objectives:
Effects of Bogijetong-tang (BJT) on peripheral nerve regeneration have been reported in a previous study on BJT but additional study on a damaged peripheral neuropathy where its damage level is physically and chemically more severe was needed. Plus, this study was conducted because there haven't been any studies for BJT on central nerve regeneration.
Methods :
In order to check the effect on central nerve regeneration, the study on cerebellum cells was started and the sciatic nerve was used to observe the effects on a peripheral nerve which was severely damaged both physically and chemically. Nerve recovery effects were observed by analyzing target proteins such as phospho-extracellular signal-regulated kinase, β1 integrin, neurofilament 200, growth-associated protein-43, cyclin-dependent kinase 1, phospho-vimentin, phospho-Smad, and caspase 3.
Results:
The significant changes of target protein in cerebellum neurons have been observed. The changes of index protein on the axon regeneration and the nerve recovery in the sciatic nerve have been observed and the effects on cell protection were observed, as well.
Conclusions:
This study confirmed that BJT made a significant influence on nerve protection and recovery of a damaged peripheral neuropathy and it also made a possibility of its regeneration in a damaged central nerve injury. |
| Key words:
Bogijetong-tang (BJT), taxol, sciatic nerve, nerve regeneration, Schwann cell, cerebellum cell |
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