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The Journal of Internal Korean Medicine > Volume 34(4); 2013 > Article
The Journal of Internal Korean Medicine 2013;34(4): 375-383.
한약재의 Cytochrome P450 결합관련 안전성에 관한 연구
유다영, 우홍정, 김영철
경희대학교 한의과대학 간계내과학교실
A Study on the Affinity of Some Medicinal Herbs to Two Cytochrome P450 Subfamilies, CYP3A4 and CYP2D6
Da-young Yoo, Hong-jung Woo, Young-chul Kim
Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University
Correspondence  Young-chul Kim ,Tel: 02-958-9122, Fax: 02-958-9120, Email: yckim@khu.ac.kr
  Published online: December 30, 2013.
ABSTRACT
Objectives:
This study was performed to investigate the metabolic site of some medicinal herbs in the liver associated with CYP (Cytochrome P450).

Methods :
Cytochrome P450 is the major enzymes involved in drug metabolism and bioactivation. CYP3A4 and CYP2D6, the major CYP isoforms in humans, catalyse the major proportion of drugs available on the market. Scintillation proximity assay (SPA) is often used in studies to identify compounds that inhibit CYP3A4 and CYP2D6. 28 herbal extracts and radioisotopes were attached competitively to SPA beads, and followed by measuring the remaining radioisotopes in the medium. Erythromycin and dexamethasone, inhibitors of CYP3A4 and CYP2D6, were used as controls respectively.

Results:
Most of the 28 herbal extracts showed dose-dependent affinity to the CYP3A4 while some of the herbs showed affinity to the CYP2D6.

Conclusions:
These results suggest that most of the 28 herbal extracts are metabolized safely in the liver, combined with CYP3A4 and CYP2D6.
Key words: herbal medicine, cytochrome P450 3A4, cytochrome P450 2D6
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