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The Journal of Internal Korean Medicine > Volume 33(2); 2012 > Article
The Journal of Internal Korean Medicine 2012;33(2): 160-171.
와파린과 상호작용하는 한약재에 대한 고찰
이인1,4, 박상무2, 박승찬3,4, 김도형3,4, 조민경4, 한창우1,4, 권정남1,4, 홍진우1,4
1부산대학교 한의학전문대학원 한의학과
2원광대학교 한의과대학 한방내과학교실
3부산대학교 한의학전문대학원 한의과학과
4부산대학교 한방병원 한방내과
Overview of the Interaction between Warfarin and Korean Herbal Medicine
In Lee1,4, Sang-moo Park2, Seung-chan Park3,4, Do-hyung Kim3,4, Min-kyoung Cho4, Chang-woo Han1,4, Jeong-nam Kwon1,4, Jin-woo Hong1,4
1Dept. of Korean Medicine, School of Korean Medicine, Pu-San National University
2Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University
3Dept. of Korean Medical Science, School of Korean Medicine, Pu-San National University
4Dept. of Internal Medicine, Korean Medicine Hospital of Pu-San National University
Correspondence  Jin-woo Hong ,Tel: 055-360-5962, Email: jwhong@pusan.ac.kr
  Published online: June 30, 2012.
Background and Objective :
Warfarin is the standard anticoagulation treatment for atrial fibrillation, venous thromboembolism (VTE), and mechanical heart valves. Close monitoring of the International Normalized Ratio (INR) is required due to the drug's very narrow therapeutic window. Many factors can affect INR levels. Drug and food interactions are frequently cited as causes of adverse events with warfarin. We discussed interactions between herbs and warfarin studied in this research.

Methods :
In this review, PubMed was used to search medical journals. Keywords “warfarin AND interaction" were applied.

55 articles were included. The possibility of correlation between warfarin and single herbal medicines such as Salviae Miltiorrhizae Radix, Angelicae Gigantis Radix, Ginseng Radix Alba, Lycii Fructus, Ginkgo Folium, Menthae Herba, Trigonellae semen was suggested. Furthermore, some herbal compounds interacting with warfarin were reported. The conclusion of studies reporting the effect of herbal medicine on warfarin were controversial due to small size or quality of research.

We suggest that we should prescribe therapeutic herbal medicines to patients using warfarin more carefully and do INR follow-up regularly.
Key words: warfarin, herbal medicine, interaction
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