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The Journal of Internal Korean Medicine 2008;29(4): 988-999. |
| 택사 열수 및 에탄올 추출물의 항산화활성과 human LDL 산화억제 및 ACE 저해효과에 미치는 영향 |
| 양영이, 이민자, 정현정, 이혜숙, 김혁, 나선택, 박선동, 박원환 |
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| Screening of Antioxidative, Anti-atherosclerotic Effect of Extracts |
| Young-yi Yang, Min-ja Lee, Hyun-jung Jung, Hye-sook Lee, Hyuck Kim, Sun-taek Na, Sun-dong Park, Won-hwan Park |
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Published online: December 30, 2008. |
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| ABSTRACT |
Objectives:
The study was conducted to evaluate antioxidative, anti-atherosclerotic and anti-hypertensive effects of
natural remedies. Alisma Rhizome (AR) has been used for a long time in Asia in folk remedies for treatment of hypertension
and stroke and has been used in Korean traditional medicine for the treatment of glycosuria, gonorrhea, hypercholesterolemia,
hypertension, and jaundice and its diuretic effect. These pharmacological effects of AR might come from antioxidant properties
of phytochemicals in these materials.
Methods :
In this study, the antioxidant activity of extract from AR was studied with in vitro methods by measuring the
antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl
radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on
Cu2+ induced human LDL oxidation and on ACE.
Results:
The AR extracts were found to have a potent scavenging activity, as well as an inhibitory effect on LDL oxidation
and on ACE against all of the reactive species tested, with the water extract showing particularly strong antioxidant activities.
Conculsions:
The AR extracts have antioxidative, anti-atherosclerotic and anti-hypertensive effects in an in vitro system,
which can be used for developing pharmaceutical drugs against oxidative stress and atherosclerosis. |
| Key words:
Alisma Rhizome (AR), antioxidative, anti-atherosclerotic, anti-hypertensive |
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