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The Journal of Internal Korean Medicine 2008;29(3): 800-809. |
| The Clinical Effect of Bosingunyang-tang on Chronic Non-bacterial Prostatitis/Chronic Pelvic Pain Syndrome : Randomized Double-blind, Placebo-controlled Clinical Trial |
| Moon-koo Song, Ji-suck Kang, Cheol-ho Kang, Young-min Ahn, Se-young Ahn, Ho-kyung Doo, Byung-cheol Lee |
| Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University |
| Correspondence |
Byung-cheol Lee ,Tel: 02-958-9182, Fax: 02-958-9158, Email: hydrolee@korea.com
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Published online: September 30, 2008. |
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| ABSTRACT |
Objective :
Although chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS) is a common disease, there is no consensus on the etiology or pathology and treatment. This was a double-blinded, placebo-controlled, randomized clinical trial, investigating the therapeutic effects of the traditional Korean medicine, Bosingunyang-tang(BSGYT).
Method:
Participants who met US National Institutes of Health (NIH) consensus criteria for CP/CPPS were entered after applying inclusion/exclusion criteria. They were randomized to the BSGYT or placebo group, and treated three times a day for 6 weeks. NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was used to estimate the clinical symptoms of CP/CPPS. Prostaglandin E2 and β-endorphin in prostatic fluid, collected by 2-glass pre-massage and post-massage test, were analyzed as factors associated with pain and inflammation.
Result:
The mean decrease in NIH-CPSI total score of the BSGYT group was 11.0 points, which is 5.7 points more than the placebo group. (Mann Whitney test P=0.038) Also the BSGYT group showed three times higher response rate than the placebo group in NIH-CPSI pain subscale score. (Fisher's exact test P=0.027) In those responders, prostaglandin E2 decreased significantly. (Wilcoxon's signed-ranks test P=0.037). No specific side effects were observed.
Conclusion:
After a 6-week treatment period, BSGYT improved clinical symptoms of CP/CPPS patients by decreasing PGE2 level in prostatic fluid. |
| Key words:
Bosingunyang-tang, chronic prostatitis, chronic pelvic pain syndrome, prostaglandin E2, Bushenjianyang-tang |
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