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The Journal of Internal Korean Medicine > Volume 29(3); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(3): 554-566.
추출 방법에 따른 甘桔湯加味方의 抗炎症, 鎭痛, 解熱, 抗酸化 및 Histamine 투과 억제효과
진형준1, 김남재2, 최혁재2, 정희재1, 정승기1
1경희대학교 한의과대학 폐계내과학 교실
2경희의료원 한방병원 한약물연구소
Anti-inflammatory Effects, Analgesic Effects, Antipyretic Effects, Anti-oxidative Effects, and Histamine Permeation Inhibition Effects of Modified Gamgil-tang per Extraction Method
Hyung-joon Jin1, Nam-jae Kim2, Hyuck-jai Choi2, Hee-jae Jung1, Sung-ki Jung1
1Department of Oriental Medicine, Graduate School of Kyung Hee University
2Research institute of Korean Herbal Medicine, Hospital of Korean Medicine, Kyung Hee University.
Correspondence  Sung-ki Jung ,Tel: 02-958-9147, Fax: 02-958-9148, Email: jskes@unitel.co.kr
  Published online: September 30, 2008.
ABSTRACT
Objectives:
Modified Gamgil-tang is a prescription commonly used for respiratory diseases. This thesis was carried out to check the treatment effects and diversity of drug formulation by comparing extraction method of ethanol and water of modified Gamgil-tang.

Methods :
All experiments were carried out with water and 50% ethanol extraction for comparison. In vivo experiment, hyaluronidase inhibitory effects and trypsin inhibitory effects were tested to measure the anti-inflammatory effects activity. Scavenging effects of DPPH free radical, xanthine oxidase inhibitory effects and inhibition on TBA-RS formation were experimented to measure anti-oxidative effects. With the in vivo experiment, ICR group mice and SD group rats were used as experimental animals. An anti-inflammatory effects experiment were carried out to measure the action on carrageenin-induced hind paw edema; analgesic effects were measured using writhing syndrome induced by 0.7% acetic acid in mice; antipyretic effect was measured using endotoxin, and inhibitory effects of increase vascular permeability induced by 0.5% histamine were measured.

Results:
For extraction of glycyrrhizin contents, ethanol extract was extracted 2 times of that of water extract. Anti-inflammatory effects showed high in ethanol extract. Anti-oxidative effects measured high in ethanol extract. No significant result was found in inhibition on TBA-RS formation. Analgesic effects were found to be similar in water and ethanol extract. Antipyretic effects were found to be stronger in water extract. Inhibitory effects of increase vascular permeability induced by 0.5% histamine showed stronger in ethanol extract.

Conclusion:
By measuring anti-inflammatory effects, analgesic effects, antipyretic effects, anti-oxidative effects, and histamine permeation inhibition effects both in water extract and ethanol extract after adding agents such as Mentha Herba, Gardeniae Fructus, and propolis to existing Gamgil-Tang, ethanol extract was found to be more effective in anti-inflammatory effects, analgesic effects, anti-oxidative effects, and histamine permeation inhibition effects. The converse was found for antipyretic effect.
Key words: Gamgil-tang, anti-inflammatory, analgesic, anti-oxidative, histamine
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