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The Journal of Internal Korean Medicine > Volume 28(3); 2007 > Article
The Journal of Internal Korean Medicine 2007;28(3): 434-441.
공복혈당수치와 운동유발전위의 상관관계에 대한 후향적 분석 : 중추운동신경과 말초운동신경의 비교
홍진우, 나병조, 박성욱, 정우상, 문상관, 박정미, 고창남, 조기호, 김영석, 배형섭
경희대학교 한의과대학 심계내과
A Retrospective Study on the Correlation between Fasting Blood Sugar and Motor Evoked Potentials : Comparison between Central and Peripheral Motor Nerve
Jin-woo Hong, Byung-jo Na, Seong-uk Park, Woo-sang Jung, Sang-kwan Moon, Jung-mi Park, Chang-nam Ko, Ki-ho Cho, Young-suk Kim, Hyung-sup Bae
Department of Cardiovascular & Neurologic Diseases (Stroke Center)
Correspondence  Jin-woo Hong ,Tel: 02-958-9289, Fax: 02-958-9132, Email: jwhong@khmc.or.kr
  Published online: September 30, 2007.
Peripheral neurodegeneration occurs in diabetes mellitus (DM), both sensory and motor nerve, but we don't know exactly if DM affects central nerve pathway for all studies. Electrophysiologic study is one of the most important diagnostic tools for diabetic neuropathy. Electroneurography and electromyography are usually used, but evoked potentials (EP) is more sensitive to small nerve fiber damages and useful for central nerve evaluation in addition to peripheral nerves. Most diabetic neuropathy studies by EP have been performed with somatosensory evoked potentials (SSEP). In contrast, the objective of this study is to investigate if DM targets central motor neurons by assessing the relation between fasting blood sugar (FBS) and motor evoked potentials (MEP) latency.

Methods :
We inspected the medical records of 34 patients who had MEP tests during admitting days. The latency from cervical portion to abductor pollicis brevis was used as peripheral motor conduction time (PMCT), and the latency from vertex to cervical portion was used as central motor conduction time (CMCT). Then, they were correlated to FBS using correlation analysis.

There was a significant linear relation between FBS and PMCT (Pearson’s correlation coefficient r=0.487, p<0.01), but a poor linear relation between FBS and CMCT (Pearson’s correlation coefficient r=-0.197, p>0.05).

This study suggests that prolonged latencies of MEP in DM may be due to peripheral neuropathy rather than dysfunction of central motor pathway, therefore the clinical use of MEP to diabetic neuropathy has to be divided segmentally.
Key words: Diabetes mellitus (DM), Diabetic neuropathy, Motor evoked potentials (MEP)
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